Effects of nicardipine on coronary, vertebral and renal arterial flows in patients with essential hypertension.
Effects of nicardipine on coronary, vertebral and renal arterial flows in patients with essential hypertension.
复制标题
尼卡地平对原发性高血压患者冠状动脉、椎动脉和肾动脉血流的影响。
DOI：
10.1291/hypres.26.193
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
I. Yamaguchi
中科院分区：
文献类型：
--
作者：
Shoji Suzuki;S. Ohtsuka;K. Ishikawa;I. Yamaguchi
我们检查了钙拮抗剂尼卡地平对主诉胸痛并接受心导管插入术的原发性高血压患者的血流动力学和左冠状动脉前降支 (LAD)、椎动脉和肾动脉血流的急性影响。使用多普勒导丝测量LAD、椎动脉和肾动脉的血流速度，并根据动脉造影测量动脉管腔直径。通过将血流速度乘以所获得的血管直径来计算动脉血流量。通过向左冠状动脉注射罂粟碱来评估冠状动脉血流储备。获得基线数据后，开始静脉输注尼卡地平，并重复相同的血流动力学、血流速度和动脉直径测量。尼卡地平输注可降低血压并增加心输出量。收缩压降低与心输出量增加之间存在相关性（r = 0.71）。 LAD、椎动脉和肾动脉的血流速度趋于增加，动脉管腔直径增加。观察到每条动脉的血流量增加和血管阻力降低（p < 0.05）。尼卡地平输注期间，LAD 动脉的舒张期血流量得到改善（p < 0.05）；然而，罂粟碱输注引起的 LAD 动脉最大血流量保持不变。因此，有证据表明，尽管血压急剧降低，但尼卡地平输注仍可改善冠状动脉、椎骨和肾脏的血流量。
We examined the acute effects of a calcium antagonist, nicardipine, on hemodynamics and blood flow in the left anterior descending coronary (LAD), vertebral and renal arteries of essential hypertensive patients who had complained of chest pain and undergone cardiac catheterization. The blood flow velocities of the LAD, vertebral and renal arteries were measured using a Doppler guidewire and the arterial luminal diameters were measured from the arteriograms. The arterial blood flow was calculated by multiplying the blood flow velocity by the obtained vessel diameter. Coronary flow reserve was evaluated by injecting papaverine into the left coronary artery. After the baseline data had been obtained, intravenous infusion of nicardipine was started and the same hemodynamic, blood flow velocity and arterial diameter measurements were repeated. Blood pressure was decreased and cardiac output was increased by nicardipine infusion. There was a correlation between the decrease in systolic blood pressure and the increase in cardiac output (r = 0.71). The blood flow velocity in the LAD, vertebral and renal arteries tended to increase and there was an increase in the arterial luminal diameter. An increase in blood flow and a lowering of vascular resistance were observed for each artery (p < 0.05). During nicardipine infusion, the diastolic blood flow in the LAD artery was improved (p < 0.05); however, the maximal blood flow in the LAD artery induced by papaverine infusion remained unchanged. Therefore, there is evidence that coronary, vertebral and renal blood flows are improved by nicardipine infusion despite the acute blood pressure reduction.
影响因子：
37.8
作者：
Vatner,SF;Shannon,R;Hittinger,L
通讯作者：
Hittinger,L
地尔硫卓对人体冠状动脉血流储备的影响。
影响因子：
37.8
作者：
Rossen,JD;Simonetti,I;Marcus,ML;Braun,P;Winniford,MD
通讯作者：
Winniford,MD
尼莫地平对脑血管收缩反应的影响。
DOI：
10.1152/ajpheart.1984.247.2.h170
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
Haws,CW;Heistad,DD
通讯作者：
Heistad,DD