Use of bipolar membrane electrodialysis (BME) in purification of l-ascorbyl-2-monophosphate
Use of bipolar membrane electrodialysis (BME) in purification of l-ascorbyl-2-monophosphate
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双极膜电渗析（BME）在 L-抗坏血酸-2-单磷酸纯化中的应用
DOI：
10.1016/j.seppur.2012.06.023
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发表时间：
2012-09
影响因子：
8.6
通讯作者：
Tianwei Tan
中科院分区：
文献类型：
--
作者：
Shuang Song;Yifeng Tao;Huaqing Shen;Biqiang Chen;Peiyong Qin;Tianwei Tan
作为维生素C的稳定替代品，1-抗坏血酸-2-单磷酸酯（AMP）在皮肤保护、皮肤处理、鱼类饲料等方面有着广泛的应用。几十年来，开发了几种生产AMP的方法。然而，没有开发出具有高收率、短路线和有限废物产生的纯化工艺。本文首次将电渗析作为一种环境友好的分离方法引入到l-抗坏血酸-2-单磷酸酯的生产中。恒电压BME工艺实现了杂质离子的“一步”去除、IAMP的脱缩醛和KOH的回收，提供了一种高效、环保的净化方法。得到AMP-酸，并可进一步生成一系列AMP盐。此外，还研究了三室单元电位差的影响。6V/Unit和5.3V/Unit下的流程既能达到高分离效率又能降低能耗，5.3V/Unit和6V/Unit在不同阶段的组合使用有望成为能耗最优的流程。
As a stable substitute of Vitamin C, l-ascorbyl-2-monophosphate (AMP) has many applications, such as skin protecting, skin treatment, and fish diary feed. For decades, several methods were developed for the production of AMP. However, no purification process with high yield, short route and limited waste production, was developed. As an environment friendly separation method, electrodialysis was introduced into the production of l-ascorbyl-2-monophosphate for the first time in this work. By achieving a ‘one-step’ removal of impurity ions, deacetalization of IAMP and recovery of KOH, the constant-voltage BME process provided an efficient and environment friendly purification method. The AMP-acid was obtained, and could further produce a series of AMP salts. In addition, the influence of potential difference per three-compartment unit was studies. Process under 6V/Unit and 5.3V/Unit achieved both high separation efficiency and low energy consumption, and the combined use of 5.3V/Unit and 6V/Unit in different stages was anticipated to be the optimum process with optimum energy consumption.
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影响因子：
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