Biventricular Myocardial Strain Analysis in Patients with Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Tissue-Tracking Technology.
Biventricular Myocardial Strain Analysis in Patients with Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Tissue-Tracking Technology.
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使用心脏磁共振组织跟踪技术对肺动脉高压患者的双心室心肌应变进行分析
DOI：
10.3390/jcm11082230
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发表时间：
2022-04-15
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
目的应用心脏磁共振组织追踪（CMR-TT）技术评价肺动脉高压（PAH）患者左、右心室（LV和RV）功能，探讨其临床应用价值。研究方法：共有79名参与者（包括47名PAH患者和32名健康对照）接受了短轴平衡稳态自由进动（SSFP）序列的心脏磁共振成像（CMRI）。采用CVI 42软件进行后处理，获得双心室心功能参数和应变参数。对所有PAH患者和心功能降低或保留的PAH患者的LV和RV应变参数进行了比较分析。结果如下：结果表明，CMR-TT在分析PAH组左、右心室整体径向应变（GRS）、环向应变（GCS）和纵向应变（GLS）方面具有较好的重复性。PAH患者左、右心室GRS、GCS和GLS（除左室GRS（LVGRS）外）均显著低于健康对照组（均p < 0.05）。PAH组中左心室和右心室的GRS和GCS显示中度相关性（分别为r = 0.323，p = 0.02; r = 0.301，p = 0.04）。与健康对照组相比，保留RV功能的PAH患者（n = 9）显示右心室的整体和节段RS、CS和LS显著降低（所有p < 0.05），基础RVGCS除外（RVGCS-b，p = 0.996）。左室功能保留的PAH患者（n = 32）和健康对照组之间仅LVGLS存在显著差异（−14.23 ± 3.01% vs. −16.79 ± 2.86%，p < 0.01）。结论：CMR-TT作为一种非放射性、无创性技术，在定量评价PAH患者左、右心室应变参数方面具有较好的可行性和可重复性，可有效检测PAH患者早期双心室心肌损害。
To evaluate both left and right ventricular (LV and RV) function in patients with pulmonary arterial hypertension (PAH) using cardiac magnetic resonance tissue-tracking (CMR-TT) technology and explore its clinical value. Methods: A total of 79 participants (including 47 patients with PAH and 32 healthy controls) underwent cardiac magnetic resonance imaging (CMRI) with a short-axis balanced steady-state free precession (SSFP) sequence. The biventricular cardiac function parameters and strain parameters were obtained by postprocessing with CVI42 software. A comparative analysis was performed between the LV and RV strain parameters in all PAH patients and in PAH patients with reduced or preserved cardiac function. Results: The results showed preferable repeatability of CMR-TT in analyzing the global radial strain (GRS), circumferential strain (GCS), and longitudinal strain (GLS) of the left and right ventricles in the PAH group. The GRS, GCS, and GLS of the left and right ventricles except for LV GRS (LVGRS) of PAH patients were significantly lower than those of healthy controls (p < 0.05 for all). The GRS and GCS of the left and right ventricles showed a moderate correlation in the PAH group (r = 0.323, p = 0.02; r = 0.301, p = 0.04, respectively). PAH patients with preserved RV function (n = 9) showed significantly decreased global and segmental RS, CS, and LS of the right ventricles than healthy controls (p < 0.05 for all), except for basal RVGCS (RVGCS-b, p = 0.996). Only the LVGLS was significantly different between the PAH patients with preserved LV function (n = 32) and the healthy controls (−14.23 ± 3.01% vs. −16.79 ± 2.86%, p < 0.01). Conclusions: As a nonradioactive and noninvasive technique, CMR-TT has preferable feasibility and repeatability in quantitatively evaluating LV and RV strain parameters in PAH patients and can be used to effectively detect early biventricular myocardial damage in patients with PAH.
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DOI：
10.1186/s12968-017-0392-0
发表时间：
2017-10-23
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
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作者：
Hwang JW;Kim SM;Park SJ;Cho EJ;Kim EK;Chang SA;Lee SC;Choe YH;Park SW
通讯作者：
Park SW
影响因子：
2.6
作者：
Saito, Takahiko;Kasai, Hajime;Tatsumi, Koichiro
通讯作者：
Tatsumi, Koichiro
影响因子：
1.8
作者：
Lindholm, Anthony;Hesselstrand, Roger;Ostenfeld, Ellen
通讯作者：
Ostenfeld, Ellen
影响因子：
2.6
作者：
Padervinskiene, Lina;Hoppenot, Deimante;Ereminiene, Egle
通讯作者：
Ereminiene, Egle
心血管磁共振的最新进展：技术和应用。
DOI：
10.1161/circimaging.116.003951
发表时间：
2017-06
期刊：
Circulation. Cardiovascular imaging
影响因子：
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作者：
Salerno M;Sharif B;Arheden H;Kumar A;Axel L;Li D;Neubauer S
通讯作者：
Neubauer S