Analysis of cytoplasmic and surface antigens in childhood T‐cell acute lymphoblastic leukaemias: clinical relevance of cytoplasmic TCRβ chain expression
Analysis of cytoplasmic and surface antigens in childhood T‐cell acute lymphoblastic leukaemias: clinical relevance of cytoplasmic TCRβ chain expression
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儿童 T 细胞急性淋巴细胞白血病的细胞质和表面抗原分析：细胞质 TCRβ 链表达的临床相关性
DOI：
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发表时间：
1994
影响因子：
6.5
通讯作者：
S. Nakazawa
中科院分区：
文献类型：
--
作者：
T. Inukai;M. Saito;Taijiro Mori;K. Nishino;T. Abe;A. Kinoshita;Toshio Suzuki;Y. Kurosawa;T. Okazaki;K. Sugita;S. Nakazawa
摘要分析了42例儿童T细胞急性淋巴细胞白血病（T-ALL）原始细胞表面和胞浆抗原的表达。除1例表达胞浆TCR δ链外，所有儿童T-ALL患者均根据胞浆CD 3（cCD 3）、TCRβ链（cTCR β）和表面CD 3（sCD 3）的差异表达分为以下3组：I组结果：1）cCD 3+、cTCRβ-、sCD 3-组8例（19.5%），cCD 3+、cTCRβ+、sCD 3-组23例（56.1%），cCD 3+、cTCRβ+、sCD 3+组10例（24.4%）。每组定义了CD 3/TCR复合物沿着胸腺内T细胞分化的逐步成熟阶段。第I组的初始WBC计数在三组中最低（P < 0.05），并且显示出显著（P < 0.05）高于第II组（0.33）的无事件生存率（0.75）。第II组和第III组之间的初始WBC计数和无事件生存期均无显著差异。因此，sCD 3阴性T-ALL中cTCRβ的缺失似乎是一个良好的预后因素，表明该分类为预测儿童T-ALL的预后提供了有用的工具。据我们所知，这是第一份研究T-ALL细胞质CD 3/TCR抗原表达与临床特征之间关系的报告。
SUMMARY. Expression of surface and cytoplasmic antigens on the blasts from 42 cases of childhood T‐cell acute lymphoblastic leukaemia (T‐ALL) were analysed. All with childhood T‐ALL, except for one case expressing cytoplasmic TCR δ chain, were classified on the basis of differential expression of cytoplasmic CD3 (cCD3), TCRβ chain (cTCR β) and surface CD3 (sCD3) into the following three groups: group I (cCD3+, cTCRβ‐, sCD3‐), eight cases (19.5%); group II (cCD3+, cTCRβ+, sCD3‐), 23 cases (56.1%); group III (cCD3+, cTCRβ+, sCD3+), 10 cases (24.4%). Each group defines the stepwise maturational stage of the CD3/TCR complex along the intrathymic T‐cell differentiation. Group I had the lowest initial WBC count among the three groups (P < 0.05) and showed significantly (P < 0.05) a higher event‐free survival (0.75) than those of group II (0.33). There was no significant difference in both the initial WBC count and the event‐free survival between groups II and III. Thus, the absence of cTCRβ in sCD3‐negative T‐ALL appears to be a good prognostic factor, suggesting that this classification provides a useful tool to predict the prognosis of childhood T‐ALL. This is the first report, to our knowledge, studying the relationship between the expression of cytoplasmic CD3/TCR antigens and the clinical features in T‐ALL.
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影响因子：
20.3
作者：
W. Crist;J. Boyett;J. Jackson;T. Vietti;M. Borowitz;A. Chauvenet;N. Winick;A. Ragab;Donald H. Mahoney;D. Head;R. Iyer;H. Wagner;J. Pullen
通讯作者：
W. Crist;J. Boyett;J. Jackson;T. Vietti;M. Borowitz;A. Chauvenet;N. Winick;A. Ragab;Donald H. Mahoney;D. Head;R. Iyer;H. Wagner;J. Pullen
影响因子：
20.3
作者：
Jonathan J. Shuster;John;Falletta;Jeanette;William;Crist;G. Humphrey;Barry;Dowell;Moody;Wharam
通讯作者：
Jonathan J. Shuster;John;Falletta;Jeanette;William;Crist;G. Humphrey;Barry;Dowell;Moody;Wharam
儿童 T 淋巴细胞恶性肿瘤的胸腺细胞和母细胞中 Leu-4 (T3) 抗原的表面和细胞质表达之间的不一致。
DOI：
10.1172/jci111954
发表时间：
1985
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Link,MP;Stewart,SJ;Warnke,RA;Levy,R
通讯作者：
Levy,R
人胎儿骨髓 B 谱系细胞中免疫球蛋白和 T 细胞受体基因重排的分析。
影响因子：
20.3
作者：
LeBien,TW;Elstrom,RL;Moseley,M;Kersey,JH;Griesinger,F
通讯作者：
Griesinger,F
影响因子：
20.3
作者：
W. Crist;A. Carroll;J. Shuster;F. Behm;M. Whitehead;T. Vietti;A. Look;D. Mahoney;A. Ragab;D. Pullen
通讯作者：
W. Crist;A. Carroll;J. Shuster;F. Behm;M. Whitehead;T. Vietti;A. Look;D. Mahoney;A. Ragab;D. Pullen