Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease.
Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease.
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DOI：
10.1016/j.preteyeres.2012.04.004
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发表时间：
2012-09
影响因子：
17.8
通讯作者：
Chan-Ling, Tailoi
中科院分区：
文献类型：
--
作者：
Kur, Joanna;Newman, Eric A.;Chan-Ling, Tailoi
关键词：
我们回顾了在健康和疾病中调节视网膜和脉络膜血流的细胞和生理机制。由于视网膜固有的光敏感性和眼底血管的直接可及性，眼睛为非侵入性研究血流调节机制提供了独特的机会。视网膜血管系统调节血流的能力与脉络膜循环调节血流的能力形成对比，脉络膜循环调节血流的能力因缺乏胶质细胞、脉络膜血管周细胞膜显著减少以及脉络膜周细胞中缺乏中间纤维而受到更多限制。我们综述了视网膜和脉络膜神经血管单位的细胞和分子组成，监测视网膜和脉络膜血流的技术，视网膜和脉络膜循环对光刺激的反应，毛细血管、星形胶质细胞和周细胞在调节血流中的作用，可能介导视网膜神经血管偶联的信号机制，以及糖尿病视网膜病变、老年性黄斑变性、青光眼和阿尔茨海默病期间视网膜和脉络膜循环的变化。最后，我们讨论了有待探索的问题。
We review the cellular and physiological mechanisms responsible for the regulation of blood flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the retina and the direct visual accessibility of fundus blood vessels, the eye offers unique opportunities for the non-invasive investigation of mechanisms of blood flow regulation. The ability of the retinal vasculature to regulate its blood flow is contrasted with the far more restricted ability of the choroidal circulation to regulate its blood flow by virtue of the absence of glial cells, the markedly reduced pericyte ensheathment of the choroidal vasculature, and the lack of intermediate filaments in choroidal pericytes. We review the cellular and molecular components of the neurovascular unit in the retina and choroid, techniques for monitoring retinal and choroidal blood flow, responses of the retinal and choroidal circulation to light stimulation, the role of capillaries, astrocytes and pericytes in regulating blood flow, putative signaling mechanisms mediating neurovascular coupling in the retina, and changes that occur in the retinal and choroidal circulation during diabetic retinopathy, age-related macular degeneration, glaucoma, and Alzheimer's disease. We close by discussing issues that remain to be explored.
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影响因子：
15.9
作者：
Barber, AJ;Lieth, E;Gardner, TW
通讯作者：
Gardner, TW
影响因子：
3.9
作者：
BILL, A;SPERBER, GO
通讯作者：
SPERBER, GO
影响因子：
4.4
作者：
Barber, Alistair J.;Gardner, Thomas W.;Abcouwer, Steven F.
通讯作者：
Abcouwer, Steven F.
影响因子：
17.8
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Anderson, Don H.;Radeke, Monte J.;Gallo, Natasha B.;Chapin, Ethan A.;Johnson, Patrick T.;Curletti, Christy R.;Hancox, Lisa S.;Hu, Jane;Ebright, Jessica N.;Malek, Goldis;Hauser, Michael A.;Rickman, Catherine Bowes;Bok, Dean;Hageman, Gregory S.;Johnson, Lincoln V.
通讯作者：
Johnson, Lincoln V.
影响因子：
4.4
作者：
Bobbie, Michael W.;Roy, Sumon;Roy, Sayon
通讯作者：
Roy, Sayon