The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.
The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.
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DOI：
10.1371/journal.pone.0025865
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Sadovsky Y
中科院分区：
文献类型：
--
作者：
Mishima T;Miner JH;Morizane M;Stahl A;Sadovsky Y
脂肪酸从母体血液摄取并经胎盘运输至胎儿循环对于胚胎发育至关重要，并且涉及多个蛋白质家族。脂肪酸转运蛋白 (FATP) 独特地将脂肪酸转运到细胞中。我们推测胎盘 FATP 与胎儿生长密切相关，并且在缺氧应激期间受到调节，这与胎儿脂肪供应减少有关。使用培养的初代人类滋养层细胞，我们发现 FATP2、FATP4 和 FATP6 在滋养层细胞中高度表达。缺氧增强了滋养层FATP2的表达，降低了FATP4的表达，而FATP6没有变化。我们还发现 Fatp2 和 Fatp4 分别在小鼠羊膜和胎盘中表达。 Fatp2或Fatp4缺陷的小鼠并没有偏离正常的孟德尔分布，胚胎和胎盘都表现出正常的重量和形态、甘油三酯含量以及与脂肪酸动员相关的基因表达。我们的结论是，尽管缺氧调节人类滋养层中 FATP2 和 FATP4 的表达，但小鼠 Fatp2 和 Fatp4 对于宫内胎儿生长并不是必需的。
The uptake and trans-placental trafficking of fatty acids from the maternal blood into the fetal circulation are essential for embryonic development, and involve several families of proteins. Fatty acid transport proteins (FATPs) uniquely transport fatty acids into cells. We surmised that placental FATPs are germane for fetal growth, and are regulated during hypoxic stress, which is associated with reduced fat supply to the fetus. Using cultured primary term human trophoblasts we found that FATP2, FATP4 and FATP6 were highly expressed in trophoblasts. Hypoxia enhanced the expression of trophoblastic FATP2 and reduced the expression of FATP4, with no change in FATP6. We also found that Fatp2 and Fatp4 are expressed in the mouse amnion and placenta, respectively. Mice deficient in Fatp2 or Fatp4 did not deviate from normal Mendelian distribution, with both embryos and placentas exhibiting normal weight and morphology, triglyceride content, and expression of genes related to fatty acid mobilization. We conclude that even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth.
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影响因子：
4.8
作者：
Gimeno, RE;Hirsch, DJ;Stahl, A
通讯作者：
Stahl, A
DOI：
10.1016/j.bbalip.2004.11.017
发表时间：
2005-02-21
影响因子：
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DOI：
10.1016/0002-9378(70)90629-0
发表时间：
1970-01-01
影响因子：
9.8
作者：
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通讯作者：
FOX, H
影响因子：
4.8
作者：
Febbraio, M;Abumrad, NA;Silverstein, RL
通讯作者：
Silverstein, RL