Kidney disease and risk of dementia: a Danish nationwide cohort study.
Kidney disease and risk of dementia: a Danish nationwide cohort study.
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肾脏疾病和痴呆症风险：丹麦全国人群研究。
DOI：
10.1136/bmjopen-2021-052652
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发表时间：
2021-10-22
期刊：
影响因子：
2.9
通讯作者：
Christiansen CF
中科院分区：
文献类型：
--
作者：
Kjaergaard AD;Johannesen BR;Sørensen HT;Henderson VW;Christiansen CF
目前尚不清楚肾脏疾病是否是患痴呆症的危险因素。我们研究了肾脏疾病与未来痴呆风险之间的关联。丹麦基于历史登记的队列研究，基于 1995 年 1 月 1 日至 2016 年 12 月 31 日的数据。所有诊断患有肾脏疾病的患者均与无肾脏疾病的一般人群队列相匹配（年龄、性别和肾脏疾病诊断年份按 1:5 匹配）。全因痴呆及其亚型：阿尔茨海默病、血管性痴呆和其他特定或未特定的痴呆。我们使用 Cox 回归分析计算了结果的 5 年累积发生率（风险）和风险比 (HR)。研究队列由 82-690 名肾病患者和 413-405 名普通人群组成。肾病患者的五年和十年死亡率是普通人群的两倍。肾病患者 5 年全因痴呆风险为 2.90%（95% 置信区间：2.78% 至 3.08%），普通人群为 2.98%（2.92% 至 3.04%）。与一般人群相比，肾病患者全因痴呆的调整后 HR 在 5 年随访中为 1.06（1.00 至 1.12），在整个研究期间为 1.08（1.03 至 1.12）。痴呆亚型的风险估计差异很大，阿尔茨海默病的风险估计较低，血管性痴呆的风险估计较高。被诊断患有肾脏疾病的患者痴呆症发病率略有增加，这主要是由血管性痴呆引起的。此外，由于高死亡率和其他更重要的合并症，肾病患者可能无法诊断出痴呆症。
It is unclear whether kidney disease is a risk factor for developing dementia. We examined the association between kidney disease and risk of future dementia. Nationwide historical registry-based cohort study in Denmark based on data from 1 January 1995 until 31 December 2016. All patients diagnosed with kidney disease and matched general population cohort without kidney disease (matched 1:5 on age, sex and year of kidney disease diagnosis). All-cause dementia and its subtypes: Alzheimer’s disease, vascular dementia and other specified or unspecified dementia. We computed 5-year cumulative incidences (risk) and hazard ratios (HRs) for outcomes using Cox regression analyses. The study cohort comprised 82 690 patients with kidney disease and 413 405 individuals from the general population. Five-year and ten-year mortality rates were twice as high in patients with kidney disease compared with the general population. The 5-year risk for all-cause dementia was 2.90% (95% confidence interval: 2.78% to 3.08%) in patients with kidney disease and 2.98% (2.92% to 3.04%) in the general population. Compared with the general population, the adjusted HRs for all-cause dementia in patients with kidney disease were 1.06 (1.00 to 1.12) for the 5-year follow-up and 1.08 (1.03 to 1.12) for the entire study period. Risk estimates for dementia subtypes differed substantially and were lower for Alzheimer’s disease and higher for vascular dementia. Patients diagnosed with kidney disease have a modestly increased rate of dementia, mainly driven by vascular dementia. Moreover, patients with kidney disease may be underdiagnosed with dementia due to high mortality and other comorbidities of higher priority.
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影响因子：
4
作者：
Thygesen SK;Christiansen CF;Christensen S;Lash TL;Sørensen HT
通讯作者：
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影响因子：
8.3
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3.9
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通讯作者：
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2.4
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