Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain.
Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain.
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DOI：
10.3390/ijms241813696
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发表时间：
2023-09-05
影响因子：
5.6
通讯作者：
Rafailov, Edik
中科院分区：
文献类型：
--
作者：
Semyachkina-Glushkovskaya, Oxana;Sokolovski, Sergey;Fedosov, Ivan;Shirokov, Alexander;Navolokin, Nikita;Bucharskaya, Alla;Blokhina, Inna;Terskov, Andrey;Dubrovski, Alexander;Telnova, Valeria;Tzven, Anna;Tzoy, Maria;Evsukova, Arina;Zhlatogosrkaya, Daria;Adushkina, Viktoria;Dmitrenko, Alexander;Manzhaeva, Maria;Krupnova, Valeria;Noghero, Alessio;Bragin, Denis;Bragina, Olga;Borisova, Ekaterina;Kurths, Juergen;Rafailov, Edik
关键词：
六十多年来，激光技术经历了一场技术革命，成为生物医学的主要工具之一，特别是在神经科学、神经退行性疾病和脑肿瘤方面。胶质母细胞瘤是最致命的脑癌，治疗选择非常有限，预后也很差。在这项对大鼠的研究中，我们证明了使用基于量子点的1267 nm激光二极管的无光敏剂激光治疗(PS-Free-LT)可以抑制胶质母细胞瘤(GBM)的生长。该波长被氧高度吸收，能够将三重态氧转变为单重态氧。总剂量为12.7kJ/cm~2的1267 nm激光照射4周后，可明显抑制基底膜的生长，使存活率从34%提高到%，其机制可能与LT激活细胞凋亡、抑制肿瘤细胞增殖、降低颅内压、刺激淋巴引流和清除功能有关。PS-FREE-LT是一项有希望的突破性技术，可用于治疗婴儿和对PSS有高光敏或过敏反应的成人浅表GBM的非侵入性或微创治疗。
Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. In this study on rats, we demonstrate that glioblastoma (GBM) growth can be suppressed by photosensitizer-free laser treatment (PS-free-LT) using a quantum-dot-based 1267 nm laser diode. This wavelength, highly absorbed by oxygen, is capable of turning triplet oxygen to singlet form. Applying 1267 nm laser irradiation for a 4 week course with a total dose of 12.7 kJ/cm2 firmly suppresses GBM growth and increases survival rate from 34% to 64%, presumably via LT-activated apoptosis, inhibition of the proliferation of tumor cells, a reduction in intracranial pressure and stimulation of the lymphatic drainage and clearing functions. PS-free-LT is a promising breakthrough technology in non- or minimally invasive therapy for superficial GBMs in infants as well as in adult patients with high photosensitivity or an allergic reaction to PSs.
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影响因子：
4.3
作者：
Li Z;Mbah NE;Maltese WA
通讯作者：
Maltese WA
DOI：
10.1186/cc2955
发表时间：
2004-10
期刊：
Critical care (London, England)
影响因子：
--
作者：
Bewick V;Cheek L;Ball J
通讯作者：
Ball J
影响因子：
4.7
作者：
Chiba, Kentaro;Aihara, Yasuo;Oda, Yuichi;Fukui, Atsushi;Tsuduki, Shunsuke;Saito, Taiichi;Nitta, Masayuki;Muragaki, Yoshihiro;Kawamata, Takakazu
通讯作者：
Kawamata, Takakazu
DOI：
10.3791/50326
发表时间：
2013-05-12
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
DeVos SL;Miller TM
通讯作者：
Miller TM
影响因子：
64.8
作者：
Ahn, Ji Hoon;Cho, Hyunsoo;Koh, Gou Young
通讯作者：
Koh, Gou Young