CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.
CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.
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CEBS - 生物系统的化学效应：一个公共数据存储库将研究设计和毒性数据与微阵列和蛋白质组学数据相结合。
DOI：
10.1093/nar/gkm755
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发表时间：
2008-01
影响因子：
14.9
通讯作者：
Fostel J
中科院分区：
文献类型：
--
作者：
Waters M;Stasiewicz S;Merrick BA;Tomer K;Bushel P;Paules R;Stegman N;Nehls G;Yost KJ;Johnson CH;Gustafson SF;Xirasagar S;Xiao N;Huang CC;Boyer P;Chan DD;Pan Q;Gong H;Taylor J;Choi D;Rashid A;Ahmed A;Howle R;Selkirk J;Tennant R;Fostel J
CEBS（生物系统中的化学效应）是一个综合的公共毒理基因组学数据库，包括研究设计和时间轴、临床化学和组织病理学发现以及微阵列和蛋白质组学数据。CEBS包含来自化学品和遗传改变研究的数据，并与临床和环境研究兼容。CEBS被设计成允许用户使用研究条件、受试者响应来查询数据，然后在已经识别出适当的受试者集合之后，移动到CEBS的微阵列模块以进行基因签名和途径分析。CEBS的范围：CEBS目前拥有22项大鼠研究，4项小鼠研究和1项秀丽隐杆线虫研究。CEBS还可以容纳来自人类受试者研究的数据。目前在CEBS中的毒理基因组学研究包括超过4000个微阵列杂交，和75个通过MALDI和MS/MS进行蛋白质鉴定注释的2D凝胶图像。CEBS包含根据MIAME指南收集的原始微阵列数据，并提供用于数据选择、预处理和分析的工具，从而产生注释的感兴趣基因列表。此外，CEBS中还纳入了1500多只动物的临床化学和组织病理学结果。CEBS/BID：BID（生物医学调查数据库）是CEBS系统的另一个组成部分。BID是一个关系数据库，用于在导出到CEBS之前加载和管理研究数据，此外还捕获和显示新的数据类型，如PCR数据或其他感兴趣的领域，包括HESI毒理学基因组学委员会定义的领域（准备中）。BID已与加拿大卫生部和美国环境保护局共享。CEBS可在www.example.com上获得。BID可通过www.example.com的用户界面访问。请求BID副本和将数据存入CEBS或BID的请求可在www.example.com上获得。
CEBS (Chemical Effects in Biological Systems) is an integrated public repository for toxicogenomics data, including the study design and timeline, clinical chemistry and histopathology findings and microarray and proteomics data. CEBS contains data derived from studies of chemicals and of genetic alterations, and is compatible with clinical and environmental studies. CEBS is designed to permit the user to query the data using the study conditions, the subject responses and then, having identified an appropriate set of subjects, to move to the microarray module of CEBS to carry out gene signature and pathway analysis. Scope of CEBS: CEBS currently holds 22 studies of rats, four studies of mice and one study of Caenorhabditis elegans. CEBS can also accommodate data from studies of human subjects. Toxicogenomics studies currently in CEBS comprise over 4000 microarray hybridizations, and 75 2D gel images annotated with protein identification performed by MALDI and MS/MS. CEBS contains raw microarray data collected in accordance with MIAME guidelines and provides tools for data selection, pre-processing and analysis resulting in annotated lists of genes of interest. Additionally, clinical chemistry and histopathology findings from over 1500 animals are included in CEBS. CEBS/BID: The BID (Biomedical Investigation Database) is another component of the CEBS system. BID is a relational database used to load and curate study data prior to export to CEBS, in addition to capturing and displaying novel data types such as PCR data, or additional fields of interest, including those defined by the HESI Toxicogenomics Committee (in preparation). BID has been shared with Health Canada and the US Environmental Protection Agency. CEBS is available at http://cebs.niehs.nih.gov. BID can be accessed via the user interface from https://dir-apps.niehs.nih.gov/arc/. Requests for a copy of BID and for depositing data into CEBS or BID are available at http://www.niehs.nih.gov/cebs-df/.
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影响因子：
1.5
作者：
Irwin, RD;Parker, JS;Boorman, GA
通讯作者：
Boorman, GA
影响因子：
1.5
作者：
Kramer, JA;Blomme, EAG;Curtiss, SW
通讯作者：
Curtiss, SW
影响因子：
3.8
作者：
Fostel, Jennifer M.;Burgoon, Lyle;Termant, Raymond
通讯作者：
Termant, Raymond
影响因子：
5.3
作者：
McElwee, JJ;Schuster, E;Gems, D
通讯作者：
Gems, D
影响因子：
4.8
作者：
McElwee, JJ;Schuster, E;Gems, D
通讯作者：
Gems, D