Myocardial ischemia in women: lessons from the NHLBI WISE study.
Myocardial ischemia in women: lessons from the NHLBI WISE study.
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DOI：
10.1002/clc.21966
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发表时间：
2012-03
影响因子：
2.7
通讯作者：
Merz, C. Noel Bairey
中科院分区：
文献类型：
--
作者：
Gulati, Martha;Shaw, Leslee J.;Merz, C. Noel Bairey
心血管疾病仍然是妇女死亡的主要原因。近30年来，死于心血管疾病的女性多于男性，最新的年度死亡率统计报告显示，美国女性死于心血管疾病的人数为421 918人。尽管女性冠心病（CHD）死亡率有显著下降，但这些下降落后于男性。此外，随着时间的推移，所有年龄组的男性冠心病死亡率都有所下降，而最年轻的女性（年龄<55岁）冠心病死亡率却显著上升。与男性相比，女性心肌缺血的患病率、症状和病理生理都存在差异。在本文中，我们回顾了女性缺血性心脏病（IHD）的病理生理学和机制，特别关注我们从WISE研究中学到的东西。我们研究了与女性心肌缺血相关的性别特异性问题，包括患病率和预后、传统和新型危险因素、诊断测试以及IHD的治疗管理策略。©2012 Wiley期刊公司。这项工作得到了国家心脏、肺和血液研究所的合同支持，编号为N01‐HV‐68161，N01‐HV‐68162,N01‐HV‐68163，N01‐HV‐68164和R01 h090957‐01A1；国家老龄研究所资助U0164829、U01 HL649141、U01 HL649241、T32HL69751和R03 AG032631‐01；国家研究资源中心的GCRC资助MO1‐RR00425；获得新泽西州丹维尔Gustavus and Louise Pfeiffer研究基金会的资助；雪松妇女协会-西奈医疗中心，洛杉矶，加利福尼亚；Edythe L. Broad女性心脏研究奖学金，Cedars - Sinai医学中心，洛杉矶，加利福尼亚；以及洛杉矶雪松西奈医学中心芭芭拉史翠珊女性心血管研究和教育项目。作者没有其他资金、财务关系或利益冲突要披露。
Cardiovascular disease (CVD) remains the leading cause of death for women. For almost 3 decades, more women than men have died from CVD, with the most recent annual statistics on mortality reporting that CVD accounted for 421 918 deaths among women in the United States. Although there have been significant declines in coronary heart disease (CHD) mortality for females, these reductions lag behind those seen in men. In addition, where there has been a decrease in mortality from CHD across all age groups over time in men, in the youngest women (age <55 years) there has been a notable increase in mortality from CHD. There are differences in the prevalence, symptoms, and pathophysiology of myocardial ischemia that occurs in women compared with men. In this paper, we review the pathophysiology and mechanisms of ischemic heart disease (IHD) in women, particularly focusing on what we have learned from the WISE study. We examine the sex‐specific issues related to myocardial ischemia in women in terms of prevalence and prognosis, traditional and novel risk factors, diagnostic testing, as well as therapeutic management strategies for IHD. © 2012 Wiley Periodicals, Inc.This work was supported by contracts from the National Heart, Lung, and Blood Institute, nos. N01‐HV‐68161, N01‐HV‐68162, N01‐HV‐68163, N01‐HV‐68164, and R01 HL090957‐01A1; grants U0164829, U01 HL649141, U01 HL649241, T32HL69751, and R03 AG032631‐01 from the National Institute on Aging; a GCRC grant MO1‐RR00425 from the National Center for Research Resources; and grants from the Gustavus and Louise Pfeiffer Research Foundation, Danville, New Jersey; the Women's Guild of Cedars‐Sinai Medical Center, Los Angeles, California; the Edythe L. Broad Women's Heart Research Fellowship, Cedars‐Sinai Medical Center, Los Angeles, California; and the Barbra Streisand Women's Cardiovascular Research and Education Program, Cedars‐Sinai Medical Center, Los Angeles. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
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