Distinguishing Different Stages of Parkinson's Disease Using Composite Index of Speed and Pen-Pressure of Sketching a Spiral.
Distinguishing Different Stages of Parkinson's Disease Using Composite Index of Speed and Pen-Pressure of Sketching a Spiral.
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DOI：
10.3389/fneur.2017.00435
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发表时间：
2017
影响因子：
3.4
通讯作者：
Raghav S
中科院分区：
文献类型：
--
作者：
Zham P;Kumar DK;Dabnichki P;Poosapadi Arjunan S;Raghav S
病情严重程度较高的帕金森病 (PD) 患者绘制螺旋时的速度和笔压较低。然而，据报道这些特征与 PD 严重程度 (SL) 之间的相关性为 0.4。需要识别具有更强相关性的参数来考虑这一点以准确诊断疾病。本研究提出使用素描的速度和笔压综合指数（CISP）作为分析PD严重程度的特征。总共招募了 28 名对照组 (CG) 和 27 名 PD 患者（总共 55 名参与者），并进行统一帕金森病评定量表 (UPDRS) 评估。他们在 A3 纸上绘制了引导阿基米德螺旋线。计算并分析速度、笔压和 CISP，以获得它们与疾病严重程度的相关性。速度、笔压和 CISP 与 PD 严重程度的相关性分别为 -0.415、-0.584 和 -0.641。 Mann-Whitney U 检验证实 CISP 适合区分 PD 和 CG，而非参数 k 样本 Kruskal-Wallis 检验证实 CISP 对于 PD SL-1 和 PD SL-3 存在显着差异。这表明，螺旋草绘期间的 CISP 可用于区分 CG 和 PD 以及 PD SL-1 和 PD SL-3，但不能用于区分 SL-2。
The speed and pen-pressure while sketching a spiral are lower among Parkinson’s disease (PD) patients with higher severity of the disease. However, the correlation between these features and the severity level (SL) of PD has been reported to be 0.4. There is a need for identifying parameters with a stronger correlation for considering this for accurate diagnosis of the disease. This study has proposed the use of the Composite Index of Speed and Pen-pressure (CISP) of sketching as a feature for analyzing the severity of PD. A total of 28 control group (CG) and 27 PD patients (total 55 participants) were recruited and assessed for Unified Parkinson’s Disease Rating Scale (UPDRS). They drew guided Archimedean spiral on an A3 sheet. Speed, pen-pressure, and CISP were computed and analyzed to obtain their correlation with severity of the disease. The correlation of speed, pen-pressure, and CISP with the severity of PD was −0.415, −0.584, and −0.641, respectively. Mann–Whitney U test confirmed that CISP was suitable to distinguish between PD and CG, while non-parametric k-sample Kruskal–Wallis test confirmed that it was significantly different for PD SL-1 and PD SL-3. This shows that CISP during spiral sketching may be used to differentiate between CG and PD and between PD SL-1 and PD SL-3 but not SL-2.
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