Vitamin D and the Liver-Correlation or Cause?

Vitamin D and the Liver-Correlation or Cause?
复制标题

DOI:
10.3390/nu10040496
复制
发表时间:
2018-04-16
期刊:
影响因子:
5.9
通讯作者:
Gunton JE
Gunton JE
中科院分区:
医学2区
文献类型:
--
作者:
Keane JT;Elangovan H;Stokes RA;Gunton JE

文献摘要

参考文献

被引文献

相似文献

维生素D作为一种重要的生理调节剂,在骨骼稳态中的经典作用之外,正变得越来越被接受。越来越多的证据将维生素D与肝脏疾病联系起来。这篇综述总结了维生素D在肝脏稳态和疾病中的作用,并讨论了基于维生素D的治疗在防止肝脏疾病进展和改善治疗反应方面的治疗潜力。虽然临床前实验数据很有希望,但围绕肝脏疾病的临床试验大多动力不足,需要进一步研究来澄清维生素D或维生素D类似物是否对肝脏疾病有有益作用。
Vitamin D is becoming increasingly accepted as an important physiological regulator outside of its classical role in skeletal homeostasis. A growing body of evidence connects vitamin D with hepatic disease. This review summarises the role of vitamin D in liver homeostasis and disease and discusses the therapeutic potential of vitamin D-based treatments to protect against hepatic disease progression and to improve response to treatment. While pre-clinical experimental data is promising, clinical trials around liver diseases have mostly been under-powered, and further studies will be required to clarify whether vitamin D or vitamin D analogues have beneficial effects on liver disease.
维生素D模拟seocalcitol的II期研究对无法手术的肝细胞癌患者。
DOI: 10.1038/sj.bjc.6601104
发表时间: 2003-07-21
影响因子: 8.8
作者:
通讯作者: --
DOI: 10.1016/j.jhep.2016.05.031
发表时间: 2016-10-01
影响因子: 25.7
作者:
Bozic, Milica;Guzman, Carla;Jover, Ramiro
通讯作者: Jover, Ramiro
DOI: 10.1016/j.jhep.2015.06.025
发表时间: 2015-11-01
影响因子: 25.7
作者:
Chan, Henry Lik-Yuen;Elkhashab, Magdy;Marcellin, Patrick
通讯作者: Marcellin, Patrick
DOI: 10.1016/j.cell.2006.06.049
发表时间: 2006-08-25
期刊: CELL
影响因子: 64.5
作者:
Bookout, Angie L.;Jeong, Yangsik;Mangelsdorf, David J.
通讯作者: Mangelsdorf, David J.
DOI: 10.3851/imp2018
发表时间: 2012-01-01
期刊: ANTIVIRAL THERAPY
影响因子: 1.2
作者:
Baur, Katharina;Mertens, Joachim C.;Geier, Andreas
通讯作者: Geier, Andreas