Vitamin D and the Liver-Correlation or Cause?
Vitamin D and the Liver-Correlation or Cause?
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DOI:
10.3390/nu10040496
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发表时间:
2018-04-16
期刊:
影响因子:
5.9
通讯作者:
Gunton JE
中科院分区:
文献类型:
--
作者:
Keane JT;Elangovan H;Stokes RA;Gunton JE
Vitamin D is becoming increasingly accepted as an important physiological regulator outside of its classical role in skeletal homeostasis. A growing body of evidence connects vitamin D with hepatic disease. This review summarises the role of vitamin D in liver homeostasis and disease and discusses the therapeutic potential of vitamin D-based treatments to protect against hepatic disease progression and to improve response to treatment. While pre-clinical experimental data is promising, clinical trials around liver diseases have mostly been under-powered, and further studies will be required to clarify whether vitamin D or vitamin D analogues have beneficial effects on liver disease.
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