Mechanisms of Chronic Metabolic Stress in Arrhythmias.

Mechanisms of Chronic Metabolic Stress in Arrhythmias.
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DOI:
10.3390/antiox9101012
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发表时间:
2020-10-19
期刊:
Antioxidants (Basel, Switzerland)
影响因子:
--
通讯作者:
Morrow JP
Morrow JP
中科院分区:
其他
文献类型:
--
作者:
Gowen BH;Reyes MV;Joseph LC;Morrow JP

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心律失常是全球许多心血管疾病相关死亡的原因。虽然心律失常的发病机制是复杂的,有越来越多的证据代谢原因。肥胖、糖尿病和长期食用高脂肪食物会显著增加心律失常的可能性。虽然这些相关性已经很好地建立起来,但将高脂饮食(HFD)与乳腺癌发生联系起来的机制解释是不完整的,尽管氧化应激似乎是至关重要的。本文综述了发生在肥胖和HFD后的代谢变化。潜在的治疗,以防止或治疗心律失常进行了讨论,包括抗氧化剂。
Cardiac arrhythmias are responsible for many cardiovascular disease-related deaths worldwide. While arrhythmia pathogenesis is complex, there is increasing evidence for metabolic causes. Obesity, diabetes, and chronically consuming high-fat foods significantly increase the likelihood of developing arrhythmias. Although these correlations are well established, mechanistic explanations connecting a high-fat diet (HFD) to arrhythmogenesis are incomplete, although oxidative stress appears to be critical. This review investigates the metabolic changes that occur in obesity and after HFD. Potential therapies to prevent or treat arrhythmias are discussed, including antioxidants.
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