Mechanisms of Chronic Metabolic Stress in Arrhythmias.
Mechanisms of Chronic Metabolic Stress in Arrhythmias.
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DOI:
10.3390/antiox9101012
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发表时间:
2020-10-19
期刊:
影响因子:
--
通讯作者:
Morrow JP
中科院分区:
文献类型:
--
作者:
Gowen BH;Reyes MV;Joseph LC;Morrow JP
Cardiac arrhythmias are responsible for many cardiovascular disease-related deaths worldwide. While arrhythmia pathogenesis is complex, there is increasing evidence for metabolic causes. Obesity, diabetes, and chronically consuming high-fat foods significantly increase the likelihood of developing arrhythmias. Although these correlations are well established, mechanistic explanations connecting a high-fat diet (HFD) to arrhythmogenesis are incomplete, although oxidative stress appears to be critical. This review investigates the metabolic changes that occur in obesity and after HFD. Potential therapies to prevent or treat arrhythmias are discussed, including antioxidants.
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影响因子:
20.1
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DOI:
10.1161/circheartfailure.115.002978
发表时间:
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期刊:
Circulation. Heart failure
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