PEBP4 promoted the growth and migration of cancer cells in pancreatic ductal adenocarcinoma
PEBP4 promoted the growth and migration of cancer cells in pancreatic ductal adenocarcinoma
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PEBP4促进胰腺导管腺癌癌细胞的生长和迁移
DOI：
10.1007/s13277-015-3906-0
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Houbao Liu
中科院分区：
文献类型：
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作者：
Han Liu;Yueqi Wang;Zhijian Cheng;Houbao Liu
胰腺导管腺癌是世界上最常见的恶性肿瘤之一。许多研究已经将AKT的激活与PDAC的进展联系起来。磷脂酰乙醇胺结合蛋白4（PEBP 4）已被报道在各种癌症类型中上调。然而，其在PDAC中的表达模式和生物学功能尚不清楚。在这项研究中，发现PEBP 4的信使RNA（mRNA）和蛋白水平在PDAC样品中升高。在PDAC细胞系中强制表达PEBP 4促进细胞生长和迁移，而通过RNA干扰（RNAi）下调PDAC细胞中的PEBP 4抑制癌细胞的生长、迁移和转移。PEBP 4与AKT相互作用，促进AKT中丝氨酸473的磷酸化。总之，本研究表明PEBP 4可能通过激活AKT信号通路促进PDAC的进展，PEBP 4可能是PDAC治疗的有希望的治疗靶点。
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common malignancies in the world. Numerous studies have linked the activation of AKT to the progression of PDAC. Phosphatidylethanolamine-binding protein 4 (PEBP4) has been reported to be upregulated in various cancer types. However, its expression pattern and biological functions in PDAC are unknown. In this study, it was found that the messenger RNA (mRNA) and protein level of PEBP4 was elevated in PDAC samples. Forced expression of PEBP4 in PDAC cell lines promoted cell growth and migration, while downregulation of PEBP4 in PDAC cells by RNA interference (RNAi) inhibited the growth, migration, and metastasis of the cancer cells. PEBP4 interacted with AKT and promoted the phosphorylation of serine 473 in AKT. Collectively, this study suggested that PEBP4 might promote the progression of PDAC through activating AKT signaling and PEBP4 might be a promising therapeutic target for PDAC treatment.
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影响因子：
--
作者：
Guiping Yu;Guo-qiang Chen;Song Wu;Kai Shen;Yong Ji
通讯作者：
Guiping Yu;Guo-qiang Chen;Song Wu;Kai Shen;Yong Ji
DOI：
10.1097/ppo.0000000000000109
发表时间：
2015-05
期刊：
Cancer journal (Sudbury, Mass.)
影响因子：
--
作者：
Dimastromatteo J;Houghton JL;Lewis JS;Kelly KA
通讯作者：
Kelly KA
影响因子：
--
作者：
Cheaib B;Auguste A;Leary A
通讯作者：
Leary A
影响因子：
--
作者：
Harrod H Ling;L. Mendoza-Viveros;N. Mehta;H. M. Cheng
通讯作者：
Harrod H Ling;L. Mendoza-Viveros;N. Mehta;H. M. Cheng
影响因子：
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作者：
Guiping Yu;Zhenya Shen;Guo-qiang Chen;Xiaomei Teng;Yanqiu Hu;Bin Huang
通讯作者：
Guiping Yu;Zhenya Shen;Guo-qiang Chen;Xiaomei Teng;Yanqiu Hu;Bin Huang