Cerebral SPECT imaging with different acquisition schemes using varying levels of multiplexing versus sensitivity in an adaptive multi-pinhole brain-dedicated scanner.
Cerebral SPECT imaging with different acquisition schemes using varying levels of multiplexing versus sensitivity in an adaptive multi-pinhole brain-dedicated scanner.
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DOI：
10.1088/2057-1976/ac25c3
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发表时间：
2021-09-22
影响因子：
1.4
通讯作者：
King MA
中科院分区：
文献类型：
--
作者：
Zeraatkar N;Kalluri KS;Auer B;May M;Richards RG;Furenlid LR;Kuo PH;King MA
多针孔准直器在针孔SPECT中的应用提高了探测灵敏度。由于使用多个针孔而在投影图像中存在多路复用可以以增加数据模糊性为代价进一步提高灵敏度。我们正在开发下一代自适应脑专用SPECT系统-AdaptiSPECT-C。AdaptiSPECT-C可以使用可适应的针孔模块来适应多路复用水平和系统灵敏度。在这项研究中，我们研究了4个数据采集方案的性能与不同的复用水平和灵敏度的脑SPECT成像。方案#1、#2和#3分别具有<1%、67%和31%的总体复用，而没有复用的第4方案被认为是基础事实。与匹配空间分辨率的双头平行孔SPECT系统相比，地面实况和方案#1-3分别具有1.0、1.7、5.1和4.0倍的灵敏度。使用定制的XCAT脑灌注数字体模模拟I-123 N-异丙基碘苯丙胺（IMP）在第99百分位体型男性中的分布。在两个计数水平（相对于推荐的临床计数水平的低计数和高计数）下进行每个方案的数据采集。具有低计数（高计数）场景的方案#1、#2和#3的归一化均方根误差（NRMSE）分别显示出与无复用地面实况的11%、4%和5%（10%、5%和6%）偏差。对于低计数和高计数场景，方案#1导致几乎所有分析的灰质大脑区域的最不准确的活动比率（AR）。进一步的方案#2或#3导致所有分析的灰质区域的低计数和高计数场景的最准确的AR值。因此，观察到，即使使用导致显著多路复用水平的这种大的头部尺寸，来自多路复用的更高的灵敏度也可以在一定程度上减轻数据模糊性并且被转换成更高质量的重建图像。
Application of multi-pinhole collimator in pinhole-based SPECT increases detection sensitivity. The presence of multiplexing in projection images due to the usage of multiple pinholes can further improve the sensitivity at the cost of adding data ambiguity. We are developing a next-generation adaptive brain-dedicated SPECT system –AdaptiSPECT-C. The AdaptiSPECT-C can adapt the multiplexing level and system sensitivity using adaptable pinhole modules. In this study, we investigated the performance of 4 data acquisition schemes with different multiplexing levels and sensitivities on cerebral SPECT imaging. Schemes #1, #2, and #3 have <1%, 67%, and 31% overall multiplexing, respectively, while the 4th scheme without multiplexing is considered as ground truth. The ground-truth and schemes #1—3 have 1.0, 1.7, 5.1, and 4.0 times higher sensitivity, respectively, compared to a dual-headed parallel-hole SPECT system at matched spatial resolution. A customized XCAT brain perfusion digital phantom emulating the distribution of I-123 N-isopropyl iodoamphetamine (IMP) in a 99th percentile size male was used for simulations. Data acquisition for each scheme was performed at two count levels (low-count and high-count relative to the recommended clinical count level). The normalized root-mean-square error(NRMSE) for schemes #1, #2, and #3 with the low-count (high-count) scenario showed 11%, 4%, and 5% (10%, 5%, and 6%) deviation, respectively, from that of the multiplex-free ground truth. For both the low-count and high-count scenarios, scheme #1 resulted in the least accurate activity ratio (AR) for almost all the analyzed gray-matter brain regions. Further schemes #2 or #3 led to the most accurate AR values with both low-count and high-count scenarios for all the analyzed gray-matter regions. It was thus observed that even with this large head size which leads to significant multiplexing levels, the higher sensitivity from multiplexing could to some extent mitigate the data ambiguity and be translated into reconstructed images of higher quality.
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DOI：
10.1080/23744235.2020.1763452
发表时间：
2020-08-01
期刊：
Infectious diseases (London, England)
影响因子：
--
作者：
Richelsen, Rasmus;Smit, Jesper;Nielsen, Henrik
通讯作者：
Nielsen, Henrik
影响因子：
2.6
作者：
Chen, Ling;Tsui, Benjamin M. W.;Mok, Greta S. P.
通讯作者：
Mok, Greta S. P.
DOI：
10.1109/trpms.2018.2831208
发表时间：
2018-09-01
影响因子：
4.4
作者：
Konik, Arda;De Beenhouwer, Jan;King, Michael A.
通讯作者：
King, Michael A.
影响因子：
1.3
作者：
Min, Byung Jun;Choi, Yong;Joung, Jinhun
通讯作者：
Joung, Jinhun
影响因子：
3.5
作者：
Pan, TS;Luo, DS;King, MA
通讯作者：
King, MA