Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.
Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141.
复制标题
人巨细胞病毒 UL141 下调自然杀伤细胞激活配体 CD155。
作者：
自然杀伤细胞（NK）在控制小鼠和人类巨细胞病毒感染中起着至关重要的作用。本研究表明，病毒UL141基因产物具有与人巨细胞病毒低传代株相关的免疫调节功能。UL141介导的有效保护细胞免受多种人类NK细胞群的杀伤，包括干扰素α刺激的大量培养，多克隆NK细胞系和大多数NK细胞克隆测试。逃避NK细胞杀伤是通过UL141阻断CD155的表面表达介导的，CD155先前被鉴定为NK细胞激活受体CD226 （DNAM-1）和CD96 （TACTILE）的配体。ul141介导效应的广度表明CD155在调节NK细胞功能中起关键作用。
Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and humans. Here we show that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus. UL141 mediated efficient protection of cells against killing by a wide range of human NK cell populations, including interferon-α-stimulated bulk cultures, polyclonal NK cell lines and most NK cell clones tested. Evasion of NK cell killing was mediated by UL141 blocking surface expression of CD155, which was previously identified as a ligand for NK cell-activating receptors CD226 (DNAM-1) and CD96 (TACTILE). The breadth of the UL141-mediated effect indicates that CD155 has a key role in regulating NK cell function.
登录
查看更多内容
影响因子：
8.6
作者：
Carr, WH;Little, AM;Parham, P
通讯作者：
Parham, P
DOI：
10.1073/pnas.93.21.11321
发表时间：
1996-10-15
影响因子：
11.1
作者：
Mocarski, ES;Kemble, GW;Greaves, RF
通讯作者：
Greaves, RF
影响因子：
3.8
作者：
Davison, AJ;Dolan, A;Hayward, GS
通讯作者：
Hayward, GS
影响因子：
5.4
作者：
Ohka, S;Matsuda, N;Nomoto, A
通讯作者：
Nomoto, A
影响因子：
32.4
作者：
Cosman, D;Müllberg, J;Chalupny, NJ
通讯作者：
Chalupny, NJ