Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age.
Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age.
复制标题
DOI：
10.1186/2040-2392-3-17
复制
发表时间：
2012-12-11
期刊：
影响因子：
6.2
通讯作者：
Baron-Cohen S
中科院分区：
文献类型：
--
作者：
Auyeung B;Ahluwalia J;Thomson L;Taylor K;Hackett G;O'Donnell KJ;Baron-Cohen S
对产前接触性类固醇激素的研究可预测 18 至 24 岁和 96 个月大的儿童患有自闭症特征。然而，尚不清楚产后接触这些激素是否具有类似的效果。这项研究比较了 18 至 24 个月大儿童的产前和产后性类固醇激素水平与自闭症特征的关系。在常规孕中期羊膜穿刺术后，测量孕妇 (n = 35) 羊水中的胎儿睾酮 (fT) 和胎儿雌二醇 (fE) 水平。当这些孩子三到四个月大时，我们收集了他们的唾液样本，并分析了产后睾酮（pT）水平。母亲们被要求填写幼儿自闭症定量检查表 (Q-CHAT)，这是一项衡量 18 至 24 个月大儿童自闭症特征的指标。 fT（但不是 pT）水平与 Q-CHAT 得分呈正相关。 fE 和 pT 水平没有表现出性别差异，并且与 fT 水平没有关系。 fT 水平是预测 Q-CHAT 分数的唯一变量。这些初步研究结果与以下假设一致：产前（但不是产后）雄激素暴露，恰逢大脑性别分化的关键时期，与 18 至 24 个月大的幼儿自闭症特征的发展有关。然而，人们认识到，在排除产后雄激素暴露对自闭症特征的影响之前，需要对更大的样本人群进行进一步的研究。这些结果也符合自闭症的胎儿雄激素理论，该理论表明雄激素激素的产前组织效应会影响晚年自闭症特征的发展。
Studies of prenatal exposure to sex steroid hormones predict autistic traits in children at 18 to 24 and at 96 months of age. However, it is not known whether postnatal exposure to these hormones has a similar effect. This study compares prenatal and postnatal sex steroid hormone levels in relation to autistic traits in 18 to 24-month-old children. Fetal testosterone (fT) and fetal estradiol (fE) levels were measured in amniotic fluid from pregnant women (n = 35) following routine second-trimester amniocentesis. Saliva samples were collected from these children when they reached three to four months of age and were analyzed for postnatal testosterone (pT) levels. Mothers were asked to complete the Quantitative Checklist for Autism in Toddlers (Q-CHAT), a measure of autistic traits in children 18 to 24 months old. fT (but not pT) levels were positively associated with scores on the Q-CHAT. fE and pT levels showed no sex differences and no relationships with fT levels. fT levels were the only variable that predicted Q-CHAT scores. These preliminary findings are consistent with the hypothesis that prenatal (but not postnatal) androgen exposure, coinciding with the critical period for sexual differentiation of the brain, is associated with the development of autistic traits in 18 to 24 month old toddlers. However, it is recognized that further work with a larger sample population is needed before the effects of postnatal androgen exposure on autistic traits can be ruled out. These results are also in line with the fetal androgen theory of autism, which suggests that prenatal, organizational effects of androgen hormones influence the development of autistic traits in later life.
登录
查看更多内容
影响因子：
4
作者：
Auyeung, Bonnie;Baron-Cohen, Simon;Hackett, Gerald
通讯作者：
Hackett, Gerald
影响因子：
10.5
作者：
Geschwind DH
通讯作者：
Geschwind DH
影响因子：
5.8
作者：
Auyeung, Bonnie;Baron-Cohen, Simon;Hackett, Gerald
通讯作者：
Hackett, Gerald
影响因子：
2.1
作者：
Lutchmaya, S;Baron-Cohen, S;Raggatt, P
通讯作者：
Raggatt, P
DOI：
10.1111/j.1469-7610.2004.00349.x
发表时间：
2005-02-01
影响因子：
7.6
作者：
Knickmeyer, R;Baron-Cohen, S;Taylor, K
通讯作者：
Taylor, K