Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies.
Treatment of Lassa virus infection in outbred guinea pigs with first-in-class human monoclonal antibodies.
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DOI：
10.1016/j.antiviral.2016.08.012
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发表时间：
2016-09
影响因子：
7.6
通讯作者：
Garry, Robert F.
中科院分区：
文献类型：
--
作者：
Cross, Robert W.;Mire, Chad E.;Branco, Luis M.;Geisbert, Joan B.;Rowland, Megan M.;Heinrich, Megan L.;Goba, Augustine;Momoh, Mambu;Grant, Donald S.;Fullah, Mohamed;Khan, Sheik Humarr;Robinson, James E.;Geisbert, Thomas W.;Garry, Robert F.
Lassa fever is a significant health threat to West African human populations with hundreds of thousands of annual cases. There are no approved medical countermeasures currently available. Compassionate use of the antiviral drug ribavirin or transfusion of convalescent serum has resulted in mixed success depending on when administered or the donor source, respectively. We previously identified several recombinant human monoclonal antibodies targeting the glycoprotein of Lassa virus with strong neutralization profiles in vitro. Here, we demonstrate remarkable therapeutic efficacy using first-in-class human antibodies in a guinea pig model of Lassa infection thereby presenting a promising treatment alternative.
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Robinson JE;Hastie KM;Cross RW;Yenni RE;Elliott DH;Rouelle JA;Kannadka CB;Smira AA;Garry CE;Bradley BT;Yu H;Shaffer JG;Boisen ML;Hartnett JN;Zandonatti MA;Rowland MM;Heinrich ML;Martínez-Sobrido L;Cheng B;de la Torre JC;Andersen KG;Goba A;Momoh M;Fullah M;Gbakie M;Kanneh L;Koroma VJ;Fonnie R;Jalloh SC;Kargbo B;Vandi MA;Gbetuwa M;Ikponmwosa O;Asogun DA;Okokhere PO;Follarin OA;Schieffelin JS;Pitts KR;Geisbert JB;Kulakoski PC;Wilson RB;Happi CT;Sabeti PC;Gevao SM;Khan SH;Grant DS;Geisbert TW;Saphire EO;Branco LM;Garry RF
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Shaffer, Jeffrey G.;Grant, Donald S.;Garry, Robert F.
通讯作者：
Garry, Robert F.