Effect of zoledronic acid and amputation on bone invasion and lung metastasis of canine osteosarcoma in nude mice.
Effect of zoledronic acid and amputation on bone invasion and lung metastasis of canine osteosarcoma in nude mice.
复制标题
DOI：
10.1007/s10585-011-9377-9
复制
发表时间：
2011-04
影响因子：
4
通讯作者：
Rosol, Thomas J.
中科院分区：
文献类型：
--
作者：
Wolfe, Tobie D.;Pillai, Smitha Pankajavally Somanathan;Hildreth, Blake Eason, III;Lanigan, Lisa G.;Martin, Chelsea K.;Werbeck, Jillian L.;Rosol, Thomas J.
骨肉瘤(OSA)是一种侵袭性、高转移性和溶骨性的原发骨肿瘤，通常影响狗和儿童的附件骨骼。目前的治疗选择包括截肢、保肢手术或姑息性放射治疗加或不加辅助化疗。抑制骨吸收的疗法，如双膦酸盐，可能是一种有效的姑息疗法，因为它可以限制那些不能接受截肢的患者的OSA局部进展。我们已经建立了一种犬骨骼OSA的小鼠模型，该模型是在体内接种OSCA40细胞后建立的，该细胞自发转移到肺部。我们证明了含氮双膦酸唑来膦酸(Zol)的治疗减少了OSA诱导的骨溶解；然而，Zol单独治疗或联合截肢并不能有效地抑制肺转移。虽然没有达到统计学意义，但截肢减少了肺转移的平均发生率；然而，当Zol被添加到治疗方案中时，这种作用被抵消。在未经治疗的小鼠中，胫骨近端松解的程度与转移发生率显著相关。这些数据支持单独截肢治疗附件阻塞性睡眠呼吸暂停，而不是截肢和ZOL相结合。然而，对于不适合截肢的患者，Zol可能是OSA的一种有效的姑息疗法，因为它减少了溶解的幅度，因此减少了骨疼痛，尽管存在增加肺转移的风险。
Osteosarcoma (OSA) is an aggressive, highly metastatic and lytic primary bone neoplasm commonly affecting the appendicular skeleton of dogs and children. Current treatment options include amputation of the afflicted limb, limb-sparing procedures, or palliative radiation with or without adjunct chemotherapy. Therapies that inhibit bone resorption, such as the bisphosphonates, may be an effective palliative therapy by limiting the local progression of OSA in those patients that are not viable candidates for amputation. We have developed a mouse model of canine skeletal OSA following intratibial inoculation of OSCA40 cells that spontaneously metastasized to the lungs. We demonstrated that therapy with a nitrogen-containing bisphosphonate, zoledronic acid (Zol), reduced OSA-induced bone lysis; however, Zol monotherapy or in combination with amputation was not effective at inhibiting pulmonary metastasis. While not reaching statistical significance, amputation of the tumor-bearing limb reduced the average incidence of lung metastases; however, this effect was nullified when Zol was added to the treatment protocol. In untreated mice, the magnitude of proximal tibial lysis was significantly correlated with the incidence of metastasis. The data support amputation alone for the management of appendicular OSA rather than combining amputation with Zol. However, in patients that are not viable candidates for amputation, Zol may be a useful palliative therapy for OSA by reducing the magnitude of lysis and therefore bone pain, despite the risk of increased pulmonary metastasis.
登录
查看更多内容
影响因子：
1.9
作者：
BACCI, G;AVELLA, M;CAMPANACCI, M
通讯作者：
CAMPANACCI, M
影响因子：
4.4
作者：
Kabelitz, D;Wesch, D;Zöller, M
通讯作者：
Zöller, M
DOI：
10.2460/javma.232.10.1504
发表时间：
2008-05-15
影响因子：
1.9
作者：
Bacon, Nicholas J.;Ehrhart, Nicole R.;Withrow, Stephen J.
通讯作者：
Withrow, Stephen J.
影响因子：
11.8
作者：
Guise, Theresa A.
通讯作者：
Guise, Theresa A.
影响因子：
5.8
作者：
Guise, Theresa A.
通讯作者：
Guise, Theresa A.