The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway.
The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway.
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肿瘤抑制因子p53对铁死亡的调控及其途径
DOI：
10.3390/ijms21218387
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发表时间：
2020-11-09
影响因子：
5.6
通讯作者：
Feng Z
中科院分区：
文献类型：
--
作者：
Liu J;Zhang C;Wang J;Hu W;Feng Z
肿瘤抑制因子p53在肿瘤抑制中起着关键作用。除肿瘤抑制外，p53还参与许多其他生物学和病理学过程，如免疫应答、母体生殖、组织缺血/再灌注损伤和神经退行性疾病。虽然人们普遍认为p53在调节细胞周期停滞、衰老和凋亡中的作用对p53在肿瘤抑制中的功能有很大贡献，但新出现的证据表明p53还通过调节许多其他细胞过程（如代谢、抗氧化防御和铁凋亡）来发挥其肿瘤抑制功能。铁凋亡是一种独特的铁依赖性形式的程序性细胞死亡驱动的脂质过氧化反应的细胞。据报道，铁凋亡与癌症、组织缺血/再灌注损伤和神经退行性疾病有关。最近的研究表明，铁凋亡可以通过p53及其信号通路以及肿瘤相关突变p53来调节。有趣的是，p53对铁凋亡的调节似乎是高度依赖于上下文的。本文就p53及其信号通路对铁凋亡调控的研究进展作一综述。进一步阐明p53在铁凋亡调控中的作用和分子机制将为癌症和其他疾病，包括神经退行性疾病和组织缺血/再灌注损伤提供新的治疗策略。
Tumor suppressor p53 plays a key role in tumor suppression. In addition to tumor suppression, p53 is also involved in many other biological and pathological processes, such as immune response, maternal reproduction, tissue ischemia/reperfusion injuries and neurodegenerative diseases. While it has been widely accepted that the role of p53 in regulation of cell cycle arrest, senescence and apoptosis contributes greatly to the function of p53 in tumor suppression, emerging evidence has implicated that p53 also exerts its tumor suppressive function through regulation of many other cellular processes, such as metabolism, anti-oxidant defense and ferroptosis. Ferroptosis is a unique iron-dependent form of programmed cell death driven by lipid peroxidation in cells. Ferroptosis has been reported to be involved in cancer, tissue ischemia/reperfusion injuries and neurodegenerative diseases. Recent studies have shown that ferroptosis can be regulated by p53 and its signaling pathway as well as tumor-associated mutant p53. Interestingly, the regulation of ferroptosis by p53 appears to be highly context-dependent. In this review, we summarize recent advances in the regulation of ferroptosis by p53 and its signaling pathway. Further elucidation of the role and molecular mechanism of p53 in ferroptosis regulation will yield new therapeutic strategies for cancer and other diseases, including neurodegenerative diseases and tissue ischemia/reperfusion injuries.
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ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
9.8
作者：
Dangelmaier, Emily;Lazar, Sarah B.;Lal, Ashish
通讯作者：
Lal, Ashish
影响因子：
21.3
作者：
Friedmann Angeli JP;Schneider M;Proneth B;Tyurina YY;Tyurin VA;Hammond VJ;Herbach N;Aichler M;Walch A;Eggenhofer E;Basavarajappa D;Rådmark O;Kobayashi S;Seibt T;Beck H;Neff F;Esposito I;Wanke R;Förster H;Yefremova O;Heinrichmeyer M;Bornkamm GW;Geissler EK;Thomas SB;Stockwell BR;O'Donnell VB;Kagan VE;Schick JA;Conrad M
通讯作者：
Conrad M
影响因子：
10.5
作者：
Basu S;Gnanapradeepan K;Barnoud T;Kung CP;Tavecchio M;Scott J;Watters A;Chen Q;Kossenkov AV;Murphy ME
通讯作者：
Murphy ME