Retinoids in the Pathogenesis and Treatment of Liver Diseases.
Retinoids in the Pathogenesis and Treatment of Liver Diseases.
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作者：
维生素A（VA）、全反式视黄醇（ROL）及其类似物统称为类维生素A。全反式视黄酸是VA的活性代谢产物，通过视黄酸受体RARα、RARβ和RARγ起作用，是多种生物学途径的有效调节剂，包括胚胎和体细胞分化、免疫功能和能量代谢。肝脏是人体维甲酸储存和代谢的主要器官。由于尚未完全了解的原因，大量证据表明，肝脏类维生素A的减少，异常的类维生素A代谢和RAR信号传导的减少与许多肝脏疾病有关，包括肝细胞癌，非酒精相关的脂肪肝疾病和酒精相关的肝脏疾病。相反，类维生素A信号传导的恢复，天然和合成类维生素A的药理学治疗，以及特定RAR的新激动剂显示出治疗许多这些肝脏疾病的有希望的益处。在这里，我们提供了一个全面的文献综述，证明了维甲酸在限制这些疾病的发病机制和治疗肝脏疾病的作用。
Vitamin A (VA), all-trans-retinol (ROL), and its analogs are collectively called retinoids. Acting through the retinoic acid receptors RARα, RARβ, and RARγ, all-trans-retinoic acid, an active metabolite of VA, is a potent regulator of numerous biological pathways, including embryonic and somatic cellular differentiation, immune functions, and energy metabolism. The liver is the primary organ for retinoid storage and metabolism in humans. For reasons that remain incompletely understood, a body of evidence shows that reductions in liver retinoids, aberrant retinoid metabolism, and reductions in RAR signaling are implicated in numerous diseases of the liver, including hepatocellular carcinoma, non-alcohol-associated fatty liver diseases, and alcohol-associated liver diseases. Conversely, restoration of retinoid signaling, pharmacological treatments with natural and synthetic retinoids, and newer agonists for specific RARs show promising benefits for treatment of a number of these liver diseases. Here we provide a comprehensive review of the literature demonstrating a role for retinoids in limiting the pathogenesis of these diseases and in the treatment of liver diseases.
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影响因子：
4.6
作者：
Napoli, Joseph L.
通讯作者：
Napoli, Joseph L.
DOI：
10.1016/j.biocel.2012.07.026
发表时间：
2012-11-01
影响因子：
4
作者：
Amengual, Jaume;Petrov, Petar;Palou, Andreu
通讯作者：
Palou, Andreu
影响因子：
7.1
作者：
AHMED, S;LEE, MA;LIEBER, CS
通讯作者：
LIEBER, CS
影响因子：
13.5
作者：
Bitetto, Davide;Bortolotti, Nadia;Toniutto, Pierluigi
通讯作者：
Toniutto, Pierluigi
影响因子：
7.1
作者：
BJORNEBOE, GEA;JOHNSEN, J;DREVON, CA
通讯作者：
DREVON, CA