Antagonism of Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Trigeminal Neuropathic Pain: Study in an Animal Model.
Antagonism of Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Trigeminal Neuropathic Pain: Study in an Animal Model.
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DOI：
10.3390/ijms19113320
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发表时间：
2018-10-25
影响因子：
5.6
通讯作者：
Deseure K
中科院分区：
文献类型：
--
作者：
Demartini C;Greco R;Zanaboni AM;Francesconi O;Nativi C;Tassorelli C;Deseure K
瞬时受体电位锚蛋白1型（TRPA 1）通道是已知的积极参与不同的疼痛条件，包括三叉神经痛，其临床治疗仍然是不令人满意的。本研究的目的是通过拮抗剂ADM_12评估TRPA 1通道在三叉神经病理性疼痛中的参与，以确定可能的治疗靶点。在眶下神经慢性压迫性损伤（IoN-CCI）后4周，在大鼠中ADM_12的单次治疗显著降低了IoN-CCI大鼠中诱导的机械性异常性疼痛。此外，ADM_12能够消除IoN-CCI大鼠三叉神经节、颈脊髓和髓质中诱导的TRPA 1、降钙素基因相关肽（CGRP）、P物质（SP）和细胞因子基因表达水平的增加。相比之下，各组之间没有显着差异，被视为CGRP和SP蛋白表达在三叉神经脊核尾侧部。ADM_12还降低了IoN-CCI后相同区域中的TRP香草素1型（TRPV 1）基因表达。我们的研究结果表明TRPA 1和TRPV 1通道参与三叉神经痛，特别是三叉神经机械性异常性疼痛。此外，它们为ADM_12用于治疗三叉神经病理性疼痛提供了依据。
Transient receptor potential ankyrin type-1 (TRPA1) channels are known to actively participate in different pain conditions, including trigeminal neuropathic pain, whose clinical treatment is still unsatisfactory. The aim of this study was to evaluate the involvement of TRPA1 channels by means of the antagonist ADM_12 in trigeminal neuropathic pain, in order to identify possible therapeutic targets. A single treatment of ADM_12 in rats 4 weeks after the chronic constriction injury of the infraorbital nerve (IoN-CCI) significantly reduced the mechanical allodynia induced in the IoN-CCI rats. Additionally, ADM_12 was able to abolish the increased levels of TRPA1, calcitonin gene-related peptide (CGRP), substance P (SP), and cytokines gene expression in trigeminal ganglia, cervical spinal cord, and medulla induced in the IoN-CCI rats. By contrast, no significant differences between groups were seen as regards CGRP and SP protein expression in the pars caudalis of the spinal nucleus of the trigeminal nerve. ADM_12 also reduced TRP vanilloid type-1 (TRPV1) gene expression in the same areas after IoN-CCI. Our findings show the involvement of both TRPA1 and TRPV1 channels in trigeminal neuropathic pain, and in particular, in trigeminal mechanical allodynia. Furthermore, they provide grounds for the use of ADM_12 in the treatment of trigeminal neuropathic pain.
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影响因子：
4.7
作者：
Dong XP;Wang X;Xu H
通讯作者：
Xu H
瞬态受体电位香草素1在炎症和败血症中的作用。
影响因子：
4.5
作者：
Devesa I;Planells-Cases R;Fernández-Ballester G;González-Ros JM;Ferrer-Montiel A;Fernández-Carvajal A
通讯作者：
Fernández-Carvajal A
影响因子：
3.6
作者：
Deseure, KR;Adriaensen, HF;Colpaert, FC
通讯作者：
Colpaert, FC
DOI：
10.1523/jneurosci.5369-07.2008
发表时间：
2008-03-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andersson DA;Gentry C;Moss S;Bevan S
通讯作者：
Bevan S
影响因子：
5
作者：
Deseure, Kristof;Breand, Sophie;Colpaert, Francis C.
通讯作者：
Colpaert, Francis C.