Discovery of adult T-cell leukemia.
Discovery of adult T-cell leukemia.
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DOI：
10.1186/1742-4690-2-16
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发表时间：
2005-03-02
期刊：
影响因子：
3.3
通讯作者：
Takatsuki K
中科院分区：
文献类型：
--
作者：
Takatsuki K
成人T细胞白血病（ATL）于1977年在日本首次报道为一种独特的临床实体。主要的身体表现是皮肤病变、淋巴结病和肝脾肿大。ATL细胞具有成熟的辅助性T细胞表型，并具有锯齿状细胞核的特征性外观。有惊人的频繁高钙血症与破骨细胞数量增加。确定这种疾病的核心是在日本西南部的一个惊人的地理聚集性和从患者细胞系中分离出人类T细胞嗜淋巴细胞病毒1型（HTLV-1）。通过国际合作进行了世界范围的流行病学研究。发现几种疾病与HTLV-1感染有关。此外，注意到免疫缺陷状态可由HTLV-1感染诱导。在日本，HTLV-1携带者估计为120万，每年诊断出700多例ATL病例。
Adult T-cell leukemia (ATL) was first reported as a distinct clinical entity in 1977 in Japan. The predominant physical findings are skin lesions, lymphadenopathy and hepatosplenomegaly. The ATL cells are of mature T-helper phenotype and have a characteristic appearance with indented nuclei. There is striking frequent hypercalcemia with increased numbers of osteoclasts. Central to the identification of the disease is a striking geographic clustering in southwestern Japan and the isolation of human T-cell lymphotropic virus type-1 (HTLV-1) from the cell lines of patients. Worldwide epidemiological studies have been made through international collaborations. Several diseases were found to be related to HTLV-1 infection. Moreover, it was noted that an immunodeficiency state may be induced by HTLV-1 infection. In Japan, HTLV-1 carriers have been estimated to be 1.2 million, and more than 700 cases of ATL have been diagnosed each year.
影响因子：
3.3
作者：
Gallo RC
通讯作者：
Gallo RC
影响因子：
20.3
作者：
UCHIYAMA, T;YODOI, J;UCHINO, H
通讯作者：
UCHINO, H