Long Non-Coding RNAs as "MYC Facilitators".

Long Non-Coding RNAs as "MYC Facilitators".
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DOI:
10.3390/pathophysiology30030030
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发表时间:
2023-09-01
期刊:
Pathophysiology : the official journal of the International Society for Pathophysiology
影响因子:
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通讯作者:
Vogt PK
Vogt PK
中科院分区:
其他
文献类型:
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作者:
García-Caballero D;Hart JR;Vogt PK

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在这篇文章中,我们讨论了一类与MYC相互作用的lncRNA(长链非编码RNA),它们具有以下标准:它们是MYC的直接转录靶点。它们的表达与MYC的表达协调。它们是持续MYC驱动的细胞增殖所必需的,并且它们对于细胞存活不是必需的。我们将这些lncRNA称为“MYC促进因子”,并讨论了这类lncRNA的两个代表性成员,SNHG17(小核RNA宿主基因)和LNROP(POU2F2的长非编码调节因子)。我们还提出了一个一般的假设,在MYC介导的转录调控lncRNA的作用。
In this article, we discuss a class of MYC-interacting lncRNAs (long non-coding RNAs) that share the following criteria: They are direct transcriptional targets of MYC. Their expression is coordinated with the expression of MYC. They are required for sustained MYC-driven cell proliferation, and they are not essential for cell survival. We refer to these lncRNAs as “MYC facilitators” and discuss two representative members of this class of lncRNAs, SNHG17 (small nuclear RNA host gene) and LNROP (long non-coding regulator of POU2F2). We also present a general hypothesis on the role of lncRNAs in MYC-mediated transcriptional regulation.
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