Long Non-Coding RNAs as "MYC Facilitators".
Long Non-Coding RNAs as "MYC Facilitators".
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DOI:
10.3390/pathophysiology30030030
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发表时间:
2023-09-01
期刊:
影响因子:
--
通讯作者:
Vogt PK
中科院分区:
文献类型:
--
作者:
García-Caballero D;Hart JR;Vogt PK
In this article, we discuss a class of MYC-interacting lncRNAs (long non-coding RNAs) that share the following criteria: They are direct transcriptional targets of MYC. Their expression is coordinated with the expression of MYC. They are required for sustained MYC-driven cell proliferation, and they are not essential for cell survival. We refer to these lncRNAs as “MYC facilitators” and discuss two representative members of this class of lncRNAs, SNHG17 (small nuclear RNA host gene) and LNROP (long non-coding regulator of POU2F2). We also present a general hypothesis on the role of lncRNAs in MYC-mediated transcriptional regulation.
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