Chemosensitization of tumors by resveratrol.
Chemosensitization of tumors by resveratrol.
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DOI：
10.1111/j.1749-6632.2010.05852.x
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发表时间：
2011-01
影响因子：
5.2
通讯作者：
Aggarwal BB
中科院分区：
文献类型：
--
作者：
Gupta SC;Kannappan R;Reuter S;Kim JH;Aggarwal BB
由于肿瘤对化疗药物产生耐药性，癌症研究界继续寻找有效的化疗增敏剂。一个有希望的可能性是使用膳食剂，使肿瘤对化疗药物敏感。在这篇综述中，我们讨论了白藜芦醇的使用可以使肿瘤细胞对化疗药物敏感。白藜芦醇致敏的肿瘤包括肺癌、急性髓性白血病、早幼粒细胞白血病、多发性骨髓瘤、前列腺癌、口腔表皮样癌和胰腺癌。化疗剂包括长春新碱、阿霉素、紫杉醇、阿霉素、顺铂、吉非替尼、5-氟尿嘧啶（5-FU）、万珂和吉西他滨。白藜芦醇对肿瘤细胞的化学增敏作用似乎是通过其调节多种细胞信号分子的能力介导的，所述细胞信号分子包括药物转运蛋白、细胞存活蛋白、细胞增殖蛋白以及NF-κB和STAT-3信号通路的成员。然而，有趣的是，这种营养品也被报道可以抑制紫杉醇、长春新碱和柔红霉素在某些肿瘤细胞中诱导的细胞凋亡。这种双重效应的潜在机制进行了讨论。总的来说，研究表明，白藜芦醇可用于使肿瘤对标准癌症化疗药物敏感。
Because tumors develop resistance to chemotherapeutic agents, the cancer research community continues to search for effective chemosensitizers. One promising possibility is to use dietary agents that sensitize tumors to the chemotherapeutics. In this review, we discuss that the use of resveratrol can sensitize tumor cells to chemotherapeutic agents. The tumors shown to be sensitized by resveratrol include lung carcinoma, acute myeloid leukemia, promyelocytic leukemia, multiple myeloma, prostate cancer, oral epidermoid carcinoma, and pancreatic cancer. The chemotherapeutic agents include vincristine, adriamycin, paclitaxel, doxorubicin, cisplatin, gefitinib, 5-Fluorouracil (5-FU), velcade, and gemcitabine. The chemosensitization of tumor cells by resveratrol appears to be mediated through its ability to modulate multiple cell signaling molecules, including drug transporters, cell survival proteins, cell proliferative proteins, and members of the NF-κB and STAT-3 signaling pathways. Interestingly, however, this nutraceutical has also been reported to suppress apoptosis induced by paclitaxel, vincristine, and daunorubicin in some tumor cells. The potential mechanisms underlying this dual effect are discussed. Overall, studies suggest that resveratrol can be used to sensitize tumors to standard cancer chemotherapeutics.
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影响因子：
20.3
作者：
Bharti, AC;Shishodia, S;Aggarwal, BB
通讯作者：
Aggarwal, BB
影响因子：
11.2
作者：
Ahn, Kwang Seok;Sethi, Gautam;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
影响因子：
9.2
作者：
Gupta, Subash C.;Kim, Ji Hye;Prasad, Sahdeo;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
影响因子：
21.3
作者：
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通讯作者：
Mittnacht, Sibylle
影响因子：
3.4
作者：
Bernhaus, Astrid;Ozsvar-Kozma, Maria;Szekeres, Thomas
通讯作者：
Szekeres, Thomas