Circulating PCSK9 levels and 2-hPG are positively correlated in metabolic diseases in a Chinese Han population.
Circulating PCSK9 levels and 2-hPG are positively correlated in metabolic diseases in a Chinese Han population.
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循环PCSK9水平和2-hPG与中国汉族人群代谢性疾病呈正相关
DOI：
10.1186/s12944-018-0658-z
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发表时间：
2018-01-17
影响因子：
4.5
通讯作者：
Zhou H
中科院分区：
文献类型：
--
作者：
Guo W;Gong Y;Gu Y;Fu Z;Fan H;Gao B;Zhu X;Fu J;Zhao Y;Sun M;Liu X;Jiang XC;Yang T;Zhou H
前言：Protein Convertase subtilisin/kexin type 9(PCSK9)在脂蛋白代谢中起重要作用，也被认为是动脉粥样硬化的重要标志。现有证据表明，激发后2小时血糖(2-HPG)可能是动脉粥样硬化的另一个生物标志物。然而，目前循环中的PCSK9和2-HPG之间的联系仍不清楚。方法来自南京地区的中国汉族受试者中国参加了75g口服葡萄糖耐量试验，其中包括糖耐量正常(n= 2 0 0)、糖调节受损(IGR，n = 2 0 0)和2型糖尿病(T2 DM，n = 2 0 0)。进行人体测量和生化测定，如血脂测量。结果糖耐量减低组(77.63 ± 28.14 ng/ml)和2型糖尿病组(90.62 ± 39.96 ng/ml)均高于正常对照组(65.33 ± 32.68 ng/ml)，且T2 DM组明显高于糖耐量减低组(p<； 0.01)。各亚组血清PCSK9水平与2-HPG、LDL-C呈正相关，而与空腹血糖(FBG)呈正相关。多元回归模型分析还发现，在所有受试组中，PCSK9水平与2-HPG密切相关。多因素Logistic回归分析显示，调整血脂水平后，PCSK9水平与T2 DM呈正相关(OR = 1.017[1.010-1.025]，p<； 0.001)。此外，在空腹血糖正常的受试者中，2-HPG水平逐渐显著升高(分别为6.68 ± 2.01，7.48 ± 2.10和8.27 ± 2.41 mm ol/L，p<； 0.01)，而在2-HPG水平正常的受试者中，2-HPG水平无明显差异。代谢性疾病患者血清PCSK9水平与2-HPG呈正相关。
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9), which plays a crucial role in lipoprotein metabolism, has been also regarded as an important marker for atherosclerosis. Available evidence indicated that 2-h postchallenge plasma glucose (2-hPG) could be another biomarker for atherosclerosis. However, currently the association between circulating PCSK9 and 2-hPG remains unclear. Here, we explored this potential link in a Chinese Han population.MethodsTotally, 600 Chinese Han subjects from Nanjing district, China, were enrolled for the 75-g oral glucose tolerance test (OGTT), and they included normal glucose tolerance (NGT,n= 200), impaired glucose regulation (IGR, n = 200), and type 2 diabetes (T2DM, n = 200). Anthropometric and biochemical determinations such as serum lipid measurements were made. A sandwich ELISA assay was performed to measure serum PCSK9 levels in all subjects.ResultsSerum PCSK9 concentrations were higher in IGR group (77.63 ± 28.14 ng/ml) and T2DM group (90.62 ± 39.96 ng/ml) than in NGT group (65.33 ± 32.68 ng/ml), and it was significantly higher in T2DM group than in IGR group (p< 0.01). Serum PCSK9 levels positively correlated with 2-hPG and LDL-C in all subgroups, but presented a positive correlation with fasting blood glucose (FBG) only in T2DM group. Using multiple regression model analysis, we also found that PCSK9 levels closely correlated with 2-hPG in all tested groups. According to multinomial logistic regression analysis, PCSK9 levels positively correlated with T2DM (OR = 1.017[1.010–1.025],p< 0.001) even after adjustment for lipid levels. Moreover, in subjects with normal FBG level, 2-hPG gradually and significantly increased across PCSK9 tertiles (6.68 ± 2.01, 7.48 ± 2.10 and 8.27 ± 2.41 mmol/L, respectively,p< 0.01); however, in subjects with normal 2-hPG levels, no such difference was observed.ConclusionsPCSK9 levels increase as glucose metabolism deteriorated. Serum PCSK9 levels positively correlated with 2-hPG in patients with metabolic diseases.
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影响因子：
39.3
作者：
Qiao, Q;Pyörälä, K;Tuomilehto, J
通讯作者：
Tuomilehto, J
影响因子：
3.5
作者：
Kato, K.;Otsuka, T.;Kawada, T.
通讯作者：
Kawada, T.
影响因子：
8.1
作者：
Sun J;Gao Y;Yao T;Huang Y;He Z;Kong X;Yu KJ;Wang RT;Guo H;Yan J;Chang Y;Chen H;Scherer PE;Liu T;Williams KW
通讯作者：
Williams KW
影响因子：
9.3
作者：
Alborn, William E.;Cao, Guoqing;Konrad, Robert J.
通讯作者：
Konrad, Robert J.
DOI：
10.1073/pnas.1534923100
发表时间：
2003-10-14
影响因子：
11.1
作者：
Horton, JD;Shah, NA;Goldstein, JL
通讯作者：
Goldstein, JL