Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.
Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis.
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DOI：
10.3389/fimmu.2018.02122
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发表时间：
2018
影响因子：
7.3
通讯作者：
Cheng Y
中科院分区：
文献类型：
--
作者：
Chen X;Hu Y;Cao Z;Liu Q;Cheng Y
研究表明，精氨酸介导的炎症在阿尔茨海默病（AD）、帕金森病（PD）和肌萎缩侧索硬化（ALS）等神经退行性疾病的发生和/或发展中起关键作用。然而，临床研究对AD、PD和ALS患者的循环中异常细胞因子水平产生了不一致的结果。先前的研究使用荟萃分析来解决AD、PD和ALS患者血液细胞因子水平的不一致数据。在此，我们对AD、PD和ALS患者的脑脊液炎性细胞因子数据进行了系统回顾，并试图采用荟萃分析技术定量总结CSF炎性细胞因子数据。从Pubmed和Web of Science中进行的系统检索识别出71篇文章，其中2629例患者和2049例对照用于荟萃分析。随机效应荟萃分析表明，与对照组相比，AD患者CSF TGF-β、MCP-1和YKL-40水平显著升高。此外，PD患者CSF中TGF-β1、IL-6和IL-1β水平升高。此外，ALS患者的G-CSF、IL-2、IL-15、IL-17、MCP-1、MIP-1α、TNF-α和VEGF水平显著高于对照组。综上所述，这些结果不仅加强了神经退行性疾病伴随炎症反应增加的临床证据，而且还揭示了AD、PD和ALS患者中枢神经系统中独特的炎症反应特征。鉴于在这项荟萃分析中发现的一些细胞因子与神经退行性疾病之间的强相关性，CSF炎性细胞因子可能在未来用作这些疾病的生物标志物。
It has been suggested that cytokine-mediated inflammation plays a key role for the onset and/or development of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). However, clinical studies have yielded inconsistent results for the aberrant cytokine levels in circulation of patients with AD, PD, and ALS. Previous studies have used meta-analysis to address the inconsistent data for blood cytokine levels in the patients with AD, PD, and ALS. Here, we performed a systemic review of cerebrospinal fluid inflammatory cytokine data in patients with AD, PD and ALS, and sought to quantitatively summarize the CSF inflammatory cytokine data with a meta-analytical technique. The systematic search from Pubmed and Web of Science identified 71 articles with 2629 patients and 2049 controls for the meta-analysis. Random-effects meta-analysis demonstrated that CSF TGF-β, MCP-1, and YKL-40 levels were significantly elevated in AD patients when compared with controls. In addition, patients with PD had heightened levels of TGF-β1, IL-6, and IL-1β in CSF. Furthermore, G-CSF, IL-2, IL-15, IL-17, MCP-1, MIP-1α, TNF-α, and VEGF levels were significantly increased in patients with ALS as compared with controls. Taken together, these results not only strengthen the clinical evidence that neurodegenerative diseases are accompanied by the increased inflammatory response, but also reveal the unique inflammatory response profile in the central nervous system of patients with AD, PD and ALS. Given the robust associations between some cytokines and neurodegenerative diseases found in this meta-analysis, CSF inflammatory cytokines may be used as biomarkers for these diseases in the future.
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影响因子：
3.8
作者：
通讯作者：
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影响因子：
105.7
作者：
Kaduszkiewicz, H;Zimmermann, T;van den Bussche, H
通讯作者：
van den Bussche, H
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作者：
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