Risk factors for surgery-related muscle quantity and muscle quality loss and their impact on outcome.
Risk factors for surgery-related muscle quantity and muscle quality loss and their impact on outcome.
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DOI：
10.1186/s40001-021-00507-9
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发表时间：
2021-04-23
影响因子：
4.2
通讯作者：
Klaase JM
中科院分区：
文献类型：
--
作者：
van Wijk L;van Duinhoven S;Liem MSL;Bouman DE;Viddeleer AR;Klaase JM
手术相关的肌肉数量损失对术后结果产生负面影响。然而，肌肉质量的变化还没有得到充分的研究。针对确定的风险因素进行围手术期干预可以改善术后结局。本研究调查了结直肠癌肝转移（CRLM）肝切除术后与手术相关的肌肉数量和质量损失以及结局的风险因素。分析了2006年至2016年期间接受肝切除术的CRLM患者的数据。肌肉数量（腰大肌指数[PMI]）和肌肉质量（腰大肌的平均肌肉辐射衰减[AMA]）使用计算机断层扫描进行测量。术后观察腰大肌PMI和AMA的变化。共分析了128例患者; 67例（52%）有手术相关的肌肉数量损失，83例（65%）有肌肉质量损失。慢性阻塞性肺疾病（COPD）（P = 0.045）和糖尿病（P = 0.003）是手术相关的肌肉量损失的危险因素。较高的年龄（P = 0.002）、开放性切除（P = 0.003）和较长的手术时间（P = 0.033）与肌肉质量损失相关。与其他类别相比，肌肉数量和质量损失的患者的总生存率较低（P = 0.049）。手术相关肌肉质量损失组的术后并发症发生率显著较高。确定了手术相关肌肉损失的风险因素。肌肉数量和质量均丧失的患者的总生存率最低。手术相关肌肉质量损失的患者并发症发生率较高。
Surgery-related loss of muscle quantity negatively affects postoperative outcomes. However, changes of muscle quality have not been fully investigated. A perioperative intervention targeting identified risk factors could improve postoperative outcome. This study investigated risk factors for surgery-related loss of muscle quantity and quality and outcomes after liver resection for colorectal liver metastasis (CRLM). Data of patients diagnosed with CRLM who underwent liver resection between 2006 and 2016 were analysed. Muscle quantity (psoas muscle index [PMI]), and muscle quality, (average muscle radiation attenuation [AMA] of the psoas), were measured using computed tomography. Changes in PMI and AMA of psoas after surgery were assessed. A total of 128 patients were analysed; 67 (52%) had surgery-related loss of muscle quantity and 83 (65%) muscle quality loss. Chronic obstructive pulmonary disease (COPD) (P = 0.045) and diabetes (P = 0.003) were risk factors for surgery-related loss of muscle quantity. A higher age (P = 0.002), open resection (P = 0.003) and longer operation time (P = 0.033) were associated with muscle quality loss. Overall survival was lower in patients with both muscle quantity and quality loss compared to other categories (P = 0.049). The rate of postoperative complications was significantly higher in the group with surgery-related loss of muscle quality. Risk factors for surgery-related muscle loss were identified. Overall survival was lowest in patients with both muscle quantity and quality loss. Complication rate was higher in patients with surgery-related loss of muscle quality.
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影响因子：
2.6
作者：
Lalmahomed, Zarina S.;Ayez, Ninos;Verhoef, Cornelis
通讯作者：
Verhoef, Cornelis
DOI：
10.1007/s00198-017-3980-9
发表时间：
2017-06
期刊：
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
影响因子：
--
作者：
Beaudart C;Dawson A;Shaw SC;Harvey NC;Kanis JA;Binkley N;Reginster JY;Chapurlat R;Chan DC;Bruyère O;Rizzoli R;Cooper C;Dennison EM;IOF-ESCEO Sarcopenia Working Group
通讯作者：
IOF-ESCEO Sarcopenia Working Group
DOI：
10.1111/apha.12224
发表时间：
2014-03
期刊：
Acta physiologica (Oxford, England)
影响因子：
--
作者：
Aubrey J;Esfandiari N;Baracos VE;Buteau FA;Frenette J;Putman CT;Mazurak VC
通讯作者：
Mazurak VC
影响因子：
4.2
作者：
Kouw, Imre W. K.;Holwerda, Andrew M.;van Loon, Luc J. C.
通讯作者：
van Loon, Luc J. C.
影响因子：
--
作者：
Dimick, JB;Cowan, JA;Upchurch, GR
通讯作者：
Upchurch, GR