Coordinated regulation of myeloid cells by tumours.

Coordinated regulation of myeloid cells by tumours.
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通过肿瘤对髓样细胞的协调调节。

DOI:
10.1038/nri3175
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发表时间:
2012-03-22
期刊:
Nature reviews. Immunology
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骨髓细胞是人体内最丰富的有核造血细胞,是具有多种不同功能的不同细胞群的集合。三组终末分化的骨髓细胞——巨噬细胞、树突状细胞和粒细胞——对于先天性和适应性免疫系统的正常功能至关重要。越来越多的证据表明,肿瘤微环境会改变骨髓细胞,并将其转化为有效的免疫抑制细胞。在这里,我们将骨髓细胞视为一个错综复杂连接的、复杂的单一系统,我们重点研究肿瘤如何操纵骨髓系统来逃避宿主的免疫反应。
Myeloid cells are the most abundant nucleated hematopoietic cells in the human body and are a collection of distinct cell populations with many diverse functions. The three groups of terminally differentiated myeloid cells — macrophages, dendritic cells and granulocytes — are essential for the normal function of both the innate and adaptive immune systems. Mounting evidence indicates that the tumour microenvironment alters myeloid cells and can convert them into potent immune suppressive cells. Here, we consider myeloid cells as an intricately connected, complex, single system and we focus on how tumours manipulate the myeloid system to evade the host immune response.
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