Human umbilical cord mesenchymal stem cells (hUCMSCs) promotes the recovery of ovarian function in a rat model of premature ovarian failure (POF)
Human umbilical cord mesenchymal stem cells (hUCMSCs) promotes the recovery of ovarian function in a rat model of premature ovarian failure (POF)
复制标题
人脐带间充质干细胞（hUCMSCs）促进卵巢早衰（POF）大鼠模型卵巢功能的恢复
DOI：
10.1080/09513590.2021.1878133
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发表时间：
2021-01
影响因子：
2
通讯作者：
Yazhong Ji
中科院分区：
文献类型：
--
作者：
Xunyi Zhang;Lina Zhang;Ying Li;Zhe Yin;Yun Feng;Yazhong Ji
为探讨人脐带间充质干细胞（human umbilical cord mesenchymal stem cells，hUCMSCs）对卵巢早衰（premature ovarian failure，POF）的预防作用，将80只6 ~ 8周龄雌性SD大鼠随机分为A、B、C、D 4组。A组为正常对照组，B、C、D组给予透明质酸糖蛋白3（pZP 3）诱导POF模型。其中，B组为模型对照组，C组为PBS卵巢注射组，D组为hUCMSCs卵巢注射组，均于造模当天注射。发情周期;治疗20 d后检测血清促黄体生成素（LH）、促卵泡生成素（FSH）水平及卵巢卵泡数。D组大鼠发情周期及激素表达趋于正常。组织学研究表明hUCMSCs移植可增加卵巢卵泡数量。结论hUCMSCs对POF大鼠有一定的预防作用。
AimsOur study was to evaluate the benefits of human umbilical cord mesenchymal stem cells (hUCMSCs) for the prevention of premature ovarian failure (POF) in a rat model.Materials and methods80 female SD rats aged between 6 and 8 weeks were randomly divided into 4 groups A, B, C and D. Rats in group A is normal control group; group B, C and D received zona pellucida glycoprotein 3 (pZP3) administration to induce POF model. Among these, group B is model control group; group C received PBS injection in ovaries and group D received hUCMSCs injection in ovaries, all injections were performed after modeling on the same day. Estrus cycle; serum hormone level of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and amount of ovarian follicles were detected 20 days after treatment.ResultsWe successfully injected hUCMSCs in the ovary tissue of a POF rat. The estrus cycle and hormone expression of the rats in group D tends to be normal. Histological studies indicated that hUCMSCs transplantation increased the amount of ovarian follicles.ConclusionsThis study shows that hUCMSCs may have a preventive effect on POF rats.
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DOI：
10.1177/1933719117732156
发表时间：
2018-07
期刊：
Reproductive science
影响因子：
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作者：
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影响因子：
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影响因子：
3.7
作者：
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通讯作者：
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DOI：
10.1038/labinvest.2012.167
发表时间：
2013-02
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
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影响因子：
3.5
作者：
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