Impact of premature ovarian failure on mortality and morbidity among Chinese women.
Impact of premature ovarian failure on mortality and morbidity among Chinese women.
复制标题
DOI：
10.1371/journal.pone.0089597
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Shu XO
中科院分区：
文献类型：
--
作者：
Wu X;Cai H;Kallianpur A;Li H;Yang G;Gao J;Xiang YB;Ji BT;Yu-Tang;Zheng W;Shu XO
评估亚洲人群中卵巢早衰（POF）与死亡率和发病率的关系。我们在参加上海妇女健康研究的36,402名绝经后妇女中发现了1,003例POF，这是一项以人群为基础的队列研究。资料分析采用考克斯回归和Logistic回归模型。校正潜在混杂因素后，我们发现POF增加了总死亡率和癌症特异性死亡率的风险（HR（95%CI）分别为1.29（1.08-1.54）和1.38（1.05-1.81））。POF还与自身免疫性疾病的高患病率相关（OR（95%CI）：1.56（1.04-2.35）），但与乳腺癌发病率降低相关（OR（95%CI）：0.59（0.38-0.91））。当从分析中排除激素替代疗法使用者时，观察到类似的结果。POF与高腰臀比有关。我们的研究结果表明，POF妇女的死亡率增加，这些妇女可能会受益于加强监测和适当的干预。
To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations. We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a population-based cohort study. Cox regression and logistic regression models were applied in data analysis. After adjustment for potential confounding factors, we found that POF increased the risk of total and cancer-specific mortality (HR (95%CIs): 1.29 (1.08–1.54) and 1.38 (1.05–1.81), respectively). POF was also associated with high prevalence of autoimmune disease (OR (95%CI): 1.56 (1.04–2.35)) but decreased incidence of breast cancer (OR (95%CI): 0.59 (0.38–0.91)). Similar results were observed when hormone replacement therapy users were excluded from the analysis. POF is associated with high waist-to-hip ratio. Our results suggest that women with POF experience increased mortality and that these women may benefit from heightened surveillance and appropriate interventions.
登录
查看更多内容
影响因子：
5.8
作者：
JUDD, HL;JUDD, GE;YEN, SSC
通讯作者：
YEN, SSC
影响因子：
3.2
作者：
BETTERLE, C;ROSSI, A;CARETTO, A
通讯作者：
CARETTO, A
影响因子：
5.6
作者：
Cooper, GS;Sandler, DP
通讯作者：
Sandler, DP
影响因子：
5.8
作者：
FORNEY, JP;MILEWICH, L;MACDONALD, PC
通讯作者：
MACDONALD, PC
影响因子：
1.6
作者：
Atay, V.;Ceyhan, T.;Muhcu, M.
通讯作者：
Muhcu, M.