The biological responses to resveratrol and other polyphenols from alcoholic beverages.
The biological responses to resveratrol and other polyphenols from alcoholic beverages.
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DOI：
10.1111/j.1530-0277.2009.00989.x
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Feick P
中科院分区：
文献类型：
--
作者：
Brown L;Kroon PA;Das DK;Das S;Tosaki A;Chan V;Singer MV;Feick P
虽然酒精饮料中过量摄入乙醇会导致多器官损伤，但适度消费，特别是红葡萄酒，可以预防全因死亡。这些保护作用可能是由于红葡萄酒中存在的生物活性化合物的复杂混合物的一种或多种组分，包括黄酮醇，单体和聚合的黄烷-3-醇，高度着色的花青素以及酚酸和芪多酚，白藜芦醇。白藜芦醇的治疗潜力，首先是癌症化学预防，然后是心脏保护，激发了许多关于可能作用机制的研究。白藜芦醇的进一步适应症已经开发出来，包括预防与年龄相关的疾病，如神经退行性疾病，炎症，糖尿病和心血管疾病。这些改善是非常相似的，但有一个重要的二分法：低剂量改善细胞存活，如在心脏和神经保护，而高剂量增加细胞死亡，如在癌症治疗。很少有研究调查红葡萄酒中其他成分的反应，但结果一般与白藜芦醇相似。如果红葡萄酒中的非酒精成分要成为治疗剂，就需要了解它们到达作用部位的能力。本文综述了近年来有关酒精饮料中非酒精成分的作用机制、潜在的治疗用途和生物利用度的研究进展，特别是白藜芦醇和其他多酚类物质。
Although excessive consumption of ethanol in alcoholic beverages causes multi-organ damage, moderate consumption, particularly of red wine, is protective against all-cause mortality. These protective effects could be due to one or many components of the complex mixture of bioactive compounds present in red wine including flavonols, monomeric and polymeric flavan-3-ols, highly coloured anthocyanins as well as phenolic acids and the stilbene polyphenol, resveratrol. The therapeutic potential of resveratrol, firstly in cancer chemoprevention and then later for cardioprotection, has stimulated many studies on the possible mechanisms of action. Further indications for resveratrol have been developed, including the prevention of age-related disorders such as neurodegenerative diseases, inflammation, diabetes and cardiovascular disease. These improvements are remarkably similar yet there is an important dichotomy: low doses improve cell survival as in cardio- and neuro-protection yet high doses increase cell death as in cancer treatment. Fewer studies have examined the responses to other components of red wine, but the results have, in general, been similar to resveratrol. If the non-alcoholic constitutents of red wine are to become therapeutic agents, their ability to get to the sites of action needs to be understood. This mini-review summarizes recent studies on the possible mechanisms of action, potential therapeutic uses and bioavailability of the non-alcoholic constitutents of alcoholic beverages, in particular resveratrol and other polyphenols.
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发表时间：
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影响因子：
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