Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders.
Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders.
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产前免疫及其对坏死性小肠结肠炎和相关新生儿疾病的影响。
DOI：
10.3389/fimmu.2021.650709
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发表时间：
2021
影响因子：
7.3
通讯作者：
Hackam DJ
中科院分区：
文献类型：
--
作者：
Sampah MES;Hackam DJ
出生前，新生儿接触病原体的机会有限。从子宫内环境到出生后环境的转变引发了新生儿宿主与各种潜在病原体之间的一系列复杂的相互作用，这些病原体在生命的最初几周内持续存在。这种转变在早产儿和极低出生体重儿的情况下特别复杂，由于免疫系统不成熟和不发达，他们可能容易患上许多疾病。这些疾病中最主要的是坏死性小肠结肠炎（NEC），这是一种导致肠道坏死的急性炎症性疾病，可以影响多个系统，如果婴儿要存活，可能会导致长期影响。在这里，我们研究了免疫系统与母体子宫环境，微生物，营养和新生儿病理学（如NEC）发病机制中的其他因素的相互作用，同时考虑到对受影响儿童长期健康的影响。
Prior to birth, the neonate has limited exposure to pathogens. The transition from the intra-uterine to the postnatal environment initiates a series of complex interactions between the newborn host and a variety of potential pathogens that persist over the first few weeks of life. This transition is particularly complex in the case of the premature and very low birth weight infant, who may be susceptible to many disorders as a result of an immature and underdeveloped immune system. Chief amongst these disorders is necrotizing enterocolitis (NEC), an acute inflammatory disorder that leads to necrosis of the intestine, and which can affect multiple systems and have the potential to result in long term effects if the infant is to survive. Here, we examine what is known about the interplay of the immune system with the maternal uterine environment, microbes, nutritional and other factors in the pathogenesis of neonatal pathologies such as NEC, while also taking into consideration the effects on the long-term health of affected children.
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影响因子：
8
作者：
Azizia, Mallika;Lloyd, Jillian;Peebles, Donald
通讯作者：
Peebles, Donald
DOI：
10.1136/fn.76.2.f128
发表时间：
1997-03-01
影响因子：
4.4
作者：
Carr, R;Modi, N
通讯作者：
Modi, N
DOI：
10.1073/pnas.0401710101
发表时间：
2004-05-11
影响因子：
11.1
作者：
Claud, EC;Lu, L;Cherayil, BJ
通讯作者：
Cherayil, BJ
影响因子：
64.8
作者：
Bouskra, Djahida;Brezillon, Christophe;Eberl, Gerard
通讯作者：
Eberl, Gerard
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J