Prenatal phthalate exposure is associated with childhood behavior and executive functioning.
Prenatal phthalate exposure is associated with childhood behavior and executive functioning.
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DOI：
10.1289/ehp.0901470
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发表时间：
2010-04
影响因子：
10.4
通讯作者：
Wolff MS
中科院分区：
文献类型：
--
作者：
Engel SM;Miodovnik A;Canfield RL;Zhu C;Silva MJ;Calafat AM;Wolff MS
实验和观察性研究报告了邻苯二甲酸酯暴露与神经发育相关的生物学后果。我们的目标是研究产前邻苯二甲酸酯暴露与4-9岁时行为和执行功能的关系。西奈山儿童环境健康研究在1998年至2002年期间在纽约市招募了多种族产前人群（n = 404）。收集孕晚期孕妇尿液并分析邻苯二甲酸酯代谢物。儿童（n = 188，n = 365访问）进行了评估的认知和行为的发展之间的4和9岁。在多变量调整模型中，低分子量（LMW）邻苯二甲酸酯代谢物的高浓度增加与攻击性评分较差[β = 1.24; 95%置信区间（CI），0.15- 2.34]、行为问题相关（β = 2.40; 95% CI，1.34-3.46），注意力问题（β = 1.29; 95% CI，0.16- 2.41），和抑郁症（β = 1.18; 95% CI，0.11-2.24）临床量表;外化问题（β = 1.75; 95% CI，0.61-2.88）和行为症状指数（β = 1.55; 95% CI，0.39-2.71）复合量表。低分子量邻苯二甲酸酯浓度的增加也与总体执行综合指数（β = 1.23; 95% CI，0.09-2.36）和情绪控制量表（β = 1.33; 95% CI，0.18- 2.49）的评分较差相关。在我们的研究中，通常发现与产前暴露于低分子量邻苯二甲酸酯相关的行为领域在临床诊断为行为或注意缺陷多动障碍的儿童中受到影响。
Experimental and observational studies have reported biological consequences of phthalate exposure relevant to neurodevelopment. Our goal was to examine the association of prenatal phthalate exposure with behavior and executive functioning at 4–9 years of age. The Mount Sinai Children’s Environmental Health Study enrolled a multiethnic prenatal population in New York City between 1998 and 2002 (n = 404). Third-trimester maternal urines were collected and analyzed for phthalate metabolites. Children (n = 188, n = 365 visits) were assessed for cognitive and behavioral development between the ages of 4 and 9 years. In multivariate adjusted models, increased loge concentrations of low molecular weight (LMW) phthalate metabolites were associated with poorer scores on the aggression [β = 1.24; 95% confidence interval (CI), 0.15– 2.34], conduct problems (β = 2.40; 95% CI, 1.34–3.46), attention problems (β = 1.29; 95% CI, 0.16– 2.41), and depression (β = 1.18; 95% CI, 0.11–2.24) clinical scales; and externalizing problems (β = 1.75; 95% CI, 0.61–2.88) and behavioral symptom index (β = 1.55; 95% CI, 0.39–2.71) composite scales. Increased loge concentrations of LMW phthalates were also associated with poorer scores on the global executive composite index (β = 1.23; 95% CI, 0.09–2.36) and the emotional control scale (β = 1.33; 95% CI, 0.18– 2.49). Behavioral domains adversely associated with prenatal exposure to LMW phthalates in our study are commonly found to be affected in children clinically diagnosed with conduct or attention deficit hyperactivity disorders.
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在多种族的城市队列中，怀孕期间室内农药接触。
影响因子：
10.4
作者：
Berkowitz, Gertrud S;Obel, Josephine;Deych, Elena;Lapinski, Robert;Godbold, James;Liu, Zhisong;Landrigan, Philip J;Wolff, Mary S
通讯作者：
Wolff, Mary S
影响因子：
10.4
作者：
HINTON, RH;MITCHELL, FE;BRIDGES, JW
通讯作者：
BRIDGES, JW
影响因子：
4.1
作者：
Breous, E;Wenzel, A;Loos, U
通讯作者：
Loos, U
影响因子：
4.3
作者：
Poon, R;Lecavalier, P;Chu, I
通讯作者：
Chu, I
影响因子：
7.4
作者：
Kato, K;Silva, MJ;Calafat, AM
通讯作者：
Calafat, AM