New approaches in the differentiation of human embryonic stem cells and induced pluripotent stem cells toward hepatocytes.
New approaches in the differentiation of human embryonic stem cells and induced pluripotent stem cells toward hepatocytes.
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DOI：
10.1007/s12015-010-9216-4
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发表时间：
2011-09
影响因子：
4.8
通讯作者：
Zern, Mark A.
中科院分区：
文献类型：
--
作者：
Behbahan, Iman Saramipoor;Duan, Yuyou;Lam, Alexander;Khoobyari, Shiva;Ma, Xiaocui;Ahuja, Tijess P.;Zern, Mark A.
关键词：
肝移植是治疗终末期肝病的唯一方法。利用肝细胞移植和生物人工肝装置作为替代治疗方法需要无限的肝细胞来源。干细胞，特别是胚胎干细胞，具有产生用于临床应用和药物开发的功能性肝细胞的能力，可以提供这个问题的答案。2006年肝脏发育机制的新发现和诱导多能干细胞的出现为肝细胞分化和干细胞在治疗应用中的应用提供了新的见解。本文旨在为科学家和医生提供这一快速发展领域的最新进展。
Orthotropic liver transplantation is the only established treatment for end-stage liver diseases. Utilization of hepatocyte transplantation and bio-artificial liver devices as alternative therapeutic approaches requires an unlimited source of hepatocytes. Stem cells, especially embryonic stem cells, possessing the ability to produce functional hepatocytes for clinical applications and drug development, may provide the answer to this problem. New discoveries in the mechanisms of liver development and the emergence of induced pluripotent stem cells in 2006 have provided novel insights into hepatocyte differentiation and the use of stem cells for therapeutic applications. This review is aimed towards providing scientists and physicians with the latest advancements in this rapidly progressing field.
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影响因子：
5.8
作者：
Ek, Monica;Soderdahl, Therese;Johansson, Inger
通讯作者：
Johansson, Inger
影响因子：
4.1
作者：
Brolen, Gabriella;Sivertsson, Louise;Heins, Nico
通讯作者：
Heins, Nico
DOI：
10.1007/bf02232323
发表时间：
1963-01-01
期刊：
AMERICAN JOURNAL OF DIGESTIVE DISEASES
影响因子：
--
作者：
COOKE, AR;SKYRING, AP;HARRISON, DD
通讯作者：
HARRISON, DD
影响因子：
3.7
作者：
Bayha E;Jørgensen MC;Serup P;Grapin-Botton A
通讯作者：
Grapin-Botton A
影响因子：
46.9
作者：
Chambers, Stuart M.;Fasano, Christopher A.;Papapetrou, Eirini P.;Tomishima, Mark;Sadelain, Michel;Studer, Lorenz
通讯作者：
Studer, Lorenz