Concentration-dependent Differences in Urinary Iodine Measurements Between Inductively Coupled Plasma Mass Spectrometry and the Sandell-Kolthoff Method.
Concentration-dependent Differences in Urinary Iodine Measurements Between Inductively Coupled Plasma Mass Spectrometry and the Sandell-Kolthoff Method.
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电感耦合等离子体质谱法和 Sandell-Kolthoff 方法之间尿碘测量的浓度依赖性差异
DOI：
10.1007/s12011-020-02381-8
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发表时间：
2021-07
影响因子：
3.9
通讯作者：
Mao J
中科院分区：
文献类型：
--
作者：
Li Y;Ding S;Han C;Liu A;Shan Z;Teng W;Mao J
采用Sandell-Kolthoff（S-K）法测定了大量的尿碘浓度（UIC）历史资料，用于碘营养监测。电感耦合等离子体质谱法（ICP-MS）和S-K法在尿碘测量中的一致性一直存在争议。本研究共纳入2064份成人尿液样本。对标准化ICP-MS和S-K法同时获得的UIC测量结果进行了分析。用ICP-MS获得的UIC显著高于用S-K方法获得的UIC（158 μg/L对148 μg/L，p< 0.001）。Bland-Altman差异图显示，两种方法之间的平均差异较小，但具有显著性，为6.12 μg/L。分层分析显示UIC < 300 μg/L组的相关系数高于UIC ≥ 300 μg/L组（0.93 vs.0.88，p = 0.0001）。S-K和ICP-MS方法之间的平均差异与UIC呈正相关。当UIC小于300 μg/L时，ICP-MS和S-K方法具有可比性;但考虑到研究目的，应谨慎比较300 - 600 μg/L之间的UIC值。如果UIC大于600 μg/L，我们不建议在碘监测研究中比较ICP-MS和S-K方法获得的UIC。
A large amount of historical data regarding urinary iodine concentration (UIC) were measured with the Sandell-Kolthoff (S-K) method for iodine nutrition surveillance. The congruence in urinary iodine measurements between inductively coupled plasma mass spectrometry (ICP-MS) and the S-K method has been debated. A total of 2064 adult urine samples were included in the present study. The UIC measurement results obtained simultaneously by standardized ICP-MS and the S-K method were analyzed. The UIC obtained with ICP-MS was significantly higher than that obtained with the S-K method (158 μg/L vs. 148 μg/L,p< 0.001). The Bland-Altman difference plot showed a small but significant mean difference of 6.12 μg/L between the two methods. The stratified analysis showed that the correlation coefficient was higher in the UIC < 300 μg/L group than the UIC ≥ 300 μg/L group (0.93 vs. 0.88,p= 0.0001). The mean difference between the S-K and ICP-MS methods was positively correlated with the UIC. The ICP-MS and S-K methods were comparable when the UIC was less than 300 μg/L; however, UIC values between 300 and 600 μg/L should be compared with caution after considering the research objective. We do not suggest comparing UICs obtained from the ICP-MS and S-K methods in iodine monitoring studies if the UIC is greater than 600 μg/L.
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