Trends in osteoporosis and mean bone density among type 2 diabetes patients in the US from 2005 to 2014.

Trends in osteoporosis and mean bone density among type 2 diabetes patients in the US from 2005 to 2014.
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DOI:
10.1038/s41598-021-83263-4
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发表时间:
2021-02-12
期刊:
影响因子:
4.6
通讯作者:
Wu Q
Wu Q
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Xu Y;Wu Q

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本研究旨在探讨过去十年中 T2DM 患者的骨骼健康状况如何变化。对 2005-2006 年至 2013-2014 年连续国家健康和营养检查调查 (NHANES) 数据进行分析,以检查 40 岁及以上 T2DM 患者和非糖尿病患者的骨矿物质密度 (BMD) 趋势以及骨质疏松症骨质减少的患病率趋势。在四个 NHANES 周期中,T2DM 患者和非糖尿病患者的股骨颈平均 BMD 经年龄和 BMI 调整后均呈线性下降(P 线性趋势 ≤ 0.009)。在患有 T2DM 的女性中,即使在调整多个协变量后,2013-2014 年的平均 BMD 仍显着低于 2005-2006 年。 2005-2014年期间,T2DM患者和非糖尿病人群骨质疏松患病率有所上升,但无显着线性趋势(均为P线性趋势 > 0.05),而两个人群骨质减少患病率呈线性上升(均为P线性趋势 < 0.04)。 2013-2014 年,T2DM 患者和非糖尿病患者的年龄和 BMI 调整后的平均 BMD 有所下降,而两组中骨质疏松和骨质减少的患病率均有所增加。
This study aimed to examine how bone health changed among T2DM patients in the past decade. Continuous National Health and Nutrition Examination Survey (NHANES) data from 2005–2006 to 2013–2014 were analyzed to examine the trends of bone mineral density (BMD) and the prevalence trends of osteoporosis osteopenia among T2DM patients and non-diabetic people aged 40 years and older. The age- and BMI-adjusted mean BMD of the femur neck for the four NHANES cycles decreased linearly in both T2DM patients and non-diabetic people (both Plinear trend ≤ 0.009). Among women with T2DM, the mean BMD in 2013–2014 was significantly lower than that in 2005–2006, even after adjusting for multiple covariates. During 2005–2014, the prevalence of osteoporosis among T2DM patients and non-diabetic people increased but with no significant linear trend (both Plinear trend > 0.05), while the prevalence of osteopenia in the two populations increased linearly (both Plinear trend < 0.04). Age- and BMI-adjusted mean BMD decreased in 2013–2014 in patients with T2DM and non-diabetic people, while the prevalence of osteoporosis and osteopenia increased in both groups.
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