Gradients of connectivity distance are anchored in primary cortex.
Gradients of connectivity distance are anchored in primary cortex.
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DOI：
10.1007/s00429-016-1333-7
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发表时间：
2017-07
影响因子：
3.1
通讯作者：
Margulies DS
中科院分区：
文献类型：
--
作者：
Oligschläger S;Huntenburg JM;Golchert J;Lauckner ME;Bonnen T;Margulies DS
远端皮层区域之间的连通性是皮层组织的一个有价值但代价高昂的特征，主要存在于异模联合皮层区域之间。最近提出的“拴系假说”将联想皮层中长距离连接的出现描述为它们与初级皮层区域空间分离的功能。在这里，我们通过表征沿皮质表面的功能连接区域之间的距离来研究这种可能性。我们发现一个区域的特征连接距离与其与初级皮质区域的距离之间存在系统的关系。具体来说，一个区域离初级感觉运动区域越远，它与皮层其他区域的功能连接就越远。连接距离的测量还捕获了大脑皮层的主要功能细分：单峰区、注意区和高阶关联区。我们的研究结果为初级皮质区域在建立与功能特化和分化相关的皮质特性的空间分布中的锚定作用提供了证据。本文的在线版本（doi:10.1007/s00429-016-1333-7）包含补充资料，仅供授权用户使用。
Connectivity between distant cortical areas is a valuable, yet costly feature of cortical organization and is predominantly found between regions of heteromodal association cortex. The recently proposed ‘tethering hypothesis’ describes the emergence of long-distance connections in association cortex as a function of their spatial separation from primary cortical regions. Here, we investigate this possibility by characterizing the distance between functionally connected areas along the cortical surface. We found a systematic relationship between an area’s characteristic connectivity distance and its distance from primary cortical areas. Specifically, the further a region is located from primary sensorimotor regions, the more distant are its functional connections with other areas of the cortex. The measure of connectivity distance also captured major functional subdivisions of the cerebral cortex: unimodal, attention, and higher-order association regions. Our findings provide evidence for the anchoring role of primary cortical regions in establishing the spatial distribution of cortical properties that are related to functional specialization and differentiation. The online version of this article (doi:10.1007/s00429-016-1333-7) contains supplementary material, which is available to authorized users.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.5
作者：
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者：
Ghosh SS
影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC