Higher body mass index is associated with more adverse changes in calf muscle characteristics in peripheral arterial disease.
Higher body mass index is associated with more adverse changes in calf muscle characteristics in peripheral arterial disease.
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DOI：
10.1016/j.jvs.2011.10.105
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发表时间：
2012-04
影响因子：
4.3
通讯作者：
McDermott, Mary M.
中科院分区：
文献类型：
--
作者：
Raval, Zankhana;Liu, Kiang;Tian, Lu;Ferrucci, Luigi;Guralnik, Jack M.;Liao, Yihua;Criqui, Michael H.;McDermott, Mary M.
旨在确定患有下肢外周动脉疾病（PAD）的参与者中较高的体重指数（BMI）是否与基线时更不利的下肢肌肉特征以及随着时间的推移肌肉的更不利变化相关。纵向观察研究。芝加哥学术医疗中心。参与者包括 425 名患有 PAD 的男性和女性以及 261 名未患有 PAD 的男性和女性。计算机断层扫描用于测量基线和每两年的小腿肌肉特征。在基线和每年测量膝关节伸展等距力量、功率和六分钟步行。基线 BMI 类别为理想 (20-25 kg/m2)、超重 (>25-30 kg/m2) 和肥胖 (>30 kg/m2)。分析根据年龄、种族、性别、踝臂指数 (ABI)、合并症和其他协变量进行调整。基线时，在 PAD 参与者中，较高的 BMI 与较大的小腿肌肉面积相关（理想 BMI：5181 mm2，超重：5513 mm2，肥胖：5695 mm2，p 趋势=0.0009）、较高的小腿肌肉脂肪百分比（分别为 6.38%、10.28%、17.44%，p 趋势<0.0001）、较低的小腿肌肉密度（p趋势<0.0001），以及更高的等距膝关节伸展强度（p 趋势=0.015）。在患有 PAD 的参与者中，较高的 BMI 与小腿肌肉面积下降幅度更大（p 趋势 = 0.030）和小腿肌肉脂肪百分比更大增加相关（p 趋势 = 0.023）。在没有 PAD 的参与者中，基线 BMI 与下肢肌肉结果随时间的变化没有显着关联。在 PAD 参与者中，较高的 BMI 与基线时较大的小腿肌肉面积相关。然而，较高的 BMI 与基线时更不利的小腿肌肉密度和脂肪百分比以及随着时间的推移小腿肌肉面积的更大下降有关。
To determine whether higher body mass index (BMI) is associated with more adverse lower extremity muscle characteristics at baseline and more adverse changes in muscle over time among participants with lower extremity peripheral arterial disease (PAD). Longitudinal, observational study. Academic medical center in Chicago. Participants were 425 men and women with PAD and 261 without PAD. Computed Tomography was used to measure calf muscle characteristics at baseline and every two years. Knee extension isometric strength, power, and six-minute walk were measured at baseline and annually. Baseline BMI categories were ideal (20-25 kg/m2), overweight (>25-30 kg/m2), and obese (>30 kg/m2). Analyses adjust for age, race, gender, ankle brachial index (ABI), comorbidities, and other covariates. At baseline, among participants with PAD, higher BMI was associated with greater calf muscle area (ideal BMI: 5181 mm2, overweight: 5513 mm2, obese: 5695 mm2, p trend=0.0009), higher calf muscle percent fat (6.38%, 10.28%, 17.44% respectively, p trend<0.0001), lower calf muscle density (p trend<0.0001), and higher isometric knee extension strength (p trend=0.015). Among participants with PAD, higher BMI was associated with greater declines in calf muscle area p trend=0.030) and greater increases in calf muscle percent fat (p trend=0.023). Among participants without PAD, there were no significant associations of baseline BMI with changes in lower extremity muscle outcomes over time. Among PAD participants, higher BMI is associated with greater calf muscle area at baseline. However, higher BMI is associated with more adverse calf muscle density and percent fat at baseline and greater declines in calf muscle area over time.
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影响因子：
24
作者：
McDermott, Mary M.;Guralnik, Jack M.;Criqui, Michael H.
通讯作者：
Criqui, Michael H.
DOI：
10.1111/j.1532-5415.2006.00700.x
发表时间：
2006-05-01
影响因子：
6.3
作者：
Curb, J. David;Ceria-Ulep, Clementina D.;Chen, Randi
通讯作者：
Chen, Randi
影响因子：
4.3
作者：
McDermott, Mary M.;Criqui, Michael H.;Pearce, William H.
通讯作者：
Pearce, William H.
影响因子：
3.3
作者：
Mitsiopoulos, N;Baumgartner, RN;Ross, R
通讯作者：
Ross, R
影响因子：
--
作者：
ALTMAN, R;ALARCON, G;WOLFE, F
通讯作者：
WOLFE, F