Clinical characteristics and prognosis of primary pancreatic carcinoid tumors: A report of 13 cases from a single institution.
Clinical characteristics and prognosis of primary pancreatic carcinoid tumors: A report of 13 cases from a single institution.
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DOI：
10.3892/ol.2014.2776
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发表时间：
2015-02
期刊：
影响因子：
2.9
通讯作者：
Tang Y
中科院分区：
文献类型：
--
作者：
Liu FH;Wang C;Xing YL;Wu JH;Tang Y
本研究旨在分析56年来天津医科大学肿瘤研究所和医院13例类胰腺肿瘤的诊断和治疗。收集分析13例患者资料，其中男5例，女8例，平均年龄50岁。采用苏木精-伊红染色和免疫组化染色检测肿瘤组织中神经元特异性烯醇化酶（NSE）、细胞角蛋白（CK）、嗜铬粒蛋白A （CgA）和突触素（Syn）的表达。受影响的患者有腹部和/或背部疼痛，没有典型的类癌综合征。根治性切除10例，局部切除1例。其余2例患者表现为远处转移，因此分别行单次和双次搭桥手术（分别为胆总管空肠吻合术和胃空肠/胆总管空肠吻合术）。CK、Syn、CgA和NSE分别阳性表达9例（69.23%）、10例（76.92%）、5例（38.46%）和8例（61.54%）。中位生存时间为26.6个月。综上所述，对于未表现出典型类癌综合征的类胰腺肿瘤患者，如本研究，可通过病理检查确诊，手术是最有效的治疗方法。
The present study aimed to analyze the diagnosis and treatment of 13 cases of pancreatic carcinoid tumors during a 56-year period at the Tianjin Medical University Cancer Institute and Hospital (Tianjin, China). The data from 13 cases, consisting of 5 males and 8 females (mean age, 50 years), were collected and analyzed. Hematoxylin-eosin and immunohistochemistry staining were performed to investigate the expression of neuron-specific enolase (NSE), cytokeratin (CK), chromogranin A (CgA) and synaptophysin (Syn) in the tumors. The affected patients suffered abdominal and/or back pain without typical carcinoid syndrome. Radical resection was performed in 10 cases and regional resection in one case. The remaining two patients exhbited remote metastasis, and so were treated with single and double bypass surgery (choledochojejunostomy and gastrojejunostomy/choledochojejunostomy, respectively). The expression of CK, Syn, CgA and NSE was positive in nine (69.23%), 10 (76.92%), five (38.46%) and eight (61.54%) cases, respectively. The median survival time was 26.6 months. In conclusion, in patients with pancreatic carcinoid tumors that exhibit no typical carcinoid syndrome, such as those in the present study, the diagnosis can be confirmed by pathological examination and surgery is the most effective treatment.
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