Pathophysiology of diarrheal disorders.

Pathophysiology of diarrheal disorders.
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腹泻疾病的病理生理学。

DOI:
10.1093/clinids/12.supplement_1.s30
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发表时间:
1990
期刊:
Reviews of infectious diseases
影响因子:
--
通讯作者:
Banwell,JG
Banwell,JG
中科院分区:
--
文献类型:
--
作者:
Banwell,JG

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旅行者腹泻在大多数情况下只是轻度或中度。因此,严重的液体和电解质损失很少遇到。肠内的分泌、渗透和炎症过程导致腹泻引起的液体和电解质损失增加。肠道运动活动障碍,加上液体分泌,也可能在导致排便频率增加方面发挥作用。几种全身性症状,如不适、疲劳、厌食、恶心和发热,通常与腹泻相关,并导致严重的发病率,这通常足以影响度假或商务旅行的有效参与。与旅行者腹泻相关的全身症状的几个假定的机制进行了讨论,根据最近的理解肠神经系统,肠肽和激素,和其他炎症介质释放的肠壁在肠道感染。
Travelers' diarrhea is only mild or moderate in the majority of cases. Consequently, severe fluid and electrolyte losses are encountered only rarely. Secretory, osmotic, and inflammatory processes in the intestine result in increased losses of fluid and electrolytes due to diarrhea. Disorders of intestinal motor activity, coupled with fluid secretion, may also have a role in causing an increase in the frequency of bowel movements. Several systemic symptoms, such as malaise, fatigue, anorexia, nausea, and fever, are commonly associated with diarrhea and contribute to significant morbidity, which is often sufficient to compromise effective participation in a vacation or business trip. Several putative mechanisms for the systemic symptoms associated with travelers' diarrhea are discussed in light of recent understanding of the enteric nervous system, intestinal neutropeptides and hormones, and other inflammatory mediators released from the bowel wall during enteric infections.
神经肽:免疫管弦乐队的指挥。
DOI: 10.1016/0024-3205(87)90405-x
发表时间: 1987
期刊: Life sciences
影响因子: 6.1
作者:
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DOI: 10.1152/ajpgi.1983.245.2.g165
发表时间: 1983
期刊: The American journal of physiology
影响因子: --
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DOI: --
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DOI: --
发表时间: 1984
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DOI: --
发表时间: 1983
期刊: Journal of the American Medical Association (JAMA)
影响因子: --
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