Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity.
Autoantibody profiles in two patients with non-autoimmune muscle disease implicate a role for gliadin autoreactivity.
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DOI：
10.1016/j.nmd.2009.12.008
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发表时间：
2010-03
影响因子：
2.8
通讯作者：
Burns, Dennis K.
中科院分区：
文献类型：
--
作者：
Olsen, Nancy J.;Prather, Heidi;Li, Quan-Zhen;Burns, Dennis K.
本案例研究的目的是研究两名抗核抗体(ANA)和Ro(SSA)自身抗体阳性的非自身免疫性肌肉疾病患者的自身反应性。来自这两个患者的血清样本被应用于具有70多个特异性的自身抗原蛋白质阵列，并与来自健康对照组和系统性红斑狼疮患者的样本进行比较。两名肌病患者的血清中都有较高水平的醇溶蛋白自身反应性，其中一名患者具有狼疮样特征的整体自身抗体谱。这些发现表明，一些被认为是非自身免疫的肌肉疾病，实际上可能具有自身免疫的特征。进一步研究亚临床面筋自身反应性在肌病综合征发病机制中的作用，有可能为这些疾病的诊断和治疗提供改进的方法。
The objective of this case study was to characterize autoreactivity in two patients with non-autoimmune forms of muscle disease who had positivity for antinuclear antibodies (ANA) and Ro (SSA) autoantibodies. Serum samples from these two patients were applied to an autoantigen protein array with more than 70 specificities and were compared to samples from healthy controls and patients with systemic lupus erythematosus. Both myopathy patients had high levels of gliadin autoreactivity in serum and one patient had an overall autoantibody profile with lupus-like features. The findings suggest that some disorders of muscle that are considered nonautoimmune, may in fact have autoimmune features. Further examination of the role of subclinical gluten autoreactivity in the pathogenesis of myopathy syndromes has the potential to suggest improved approaches to diagnosis and treatment of these conditions.
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