Maturation of the filaria Litomosoides sigmodontis in BALB/c mice; comparative susceptibility of nine other inbred strains.
Maturation of the filaria Litomosoides sigmodontis in BALB/c mice; comparative susceptibility of nine other inbred strains.
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乙状丝虫丝虫在 BALB/c 小鼠中的成熟；
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Odile Bain
中科院分区：
文献类型：
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作者：
G. Petit;M. Diagne;P. Maréchal;D. Owen;D. Taylor;Odile Bain
在BALB基因背景（BALB/c， BALB/K和BALB/B，分别为H-2d， H-2k和H-2b单倍型）的小鼠中皮下接种后，感染L. sigmodontis的幼虫发育完全，并产生明显的微丝虫病。最敏感的菌株是BALB/c，所有小鼠都携带成丝虫病，47%的小鼠表现为明显的微丝虫病。具有B10基因背景的小鼠（B10、B10Br和B10D2，分别具有H-2b、H-2k和H-2d单倍型）几乎完全抵抗感染。从CBA/Ca、CBA/HN、C3H/HeN、DBA/2N菌株的小鼠身上均检出成虫。然而，寄生虫的位置和结构发育在每个菌株中都是不同的。微丝虫病的不存在与针状体缺失或异常、雌丝虫数减少和雌丝虫体小有关。这些结果表明，主要组织相容性复合体仅在背景基因的限制下调节丝虫的发育模式。雄性CBA/HN和C3H/HeN比雌性更易感染。菌株BALB/c出现相反的现象；DBA/D2N无宿主性别效应。
When inoculated subcutaneously, the infective larvae of L. sigmodontis undergo complete development and produce a patent microfilaraemia in mice of the BALB background (BALB/c, BALB/K and BALB/B, with respectively the H-2d, H-2k et H-2b haplotypes). The most susceptible strain is BALB/c with all mice harbouring adult filariae and 47% of mice presenting with a patent microfilaraemia. Mice with the B10 background (B10, B10Br and B10D2, with respectively the H-2b, H-2k et H-2d haplotypes) are almost completely resistant to infection. Adult filariae were recovered from all mice of the CBA/Ca, CBA/HN, C3H/HeN, DBA/2N strains. However, the site and structural development of the parasite varied in each strain. Absence of microfilaraemia is associated with absent or abnormal spicules, reduced number of female filariae and small size of female filariae. These results show that the Major Histocompatibility Complex only modulates the developmental pattern of filariae within the limits imposed by background genes. Male CBA/HN and C3H/HeN were more susceptible to infection than female mice. Inverse phenomenon was observed with strains BALB/c; and, no host sex effect was seen in DBA/D2N.
影响新生小鼠对彭亨布鲁虫感染易感性的参数。
DOI：
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发表时间：
1983
期刊：
The Journal of parasitology
影响因子：
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作者：
Furman,A;Ash,LR
通讯作者：
Ash,LR
小鼠 1 号染色体上控制鼠伤寒沙门氏菌抗性的基因的位置。
影响因子：
3.1
作者：
Taylor,BA;O'Brien,AD
通讯作者：
O'Brien,AD
马来丝虫、巴氏丝虫和彭亨丝虫对免疫缺陷裸鼠的不同致病性。
影响因子：
2.7
作者：
Vickery,AC;Nayar,JK;Albertine,KH
通讯作者：
Albertine,KH