A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
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DOI：
10.1038/ng.2608
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发表时间：
2013-06
期刊：
影响因子：
30.8
通讯作者：
Haiman, Christopher A.
中科院分区：
文献类型：
--
作者：
Monda, Keri L.;Chen, Gary K.;Taylor, Kira C.;Palmer, Cameron;Edwards, Todd L.;Lange, Leslie A.;Ng, Maggie C. Y.;Adeyemo, Adebowale A.;Allison, Matthew A.;Bielak, Lawrence F.;Chen, Guanjie;Graff, Mariaelisa;Irvin, Marguerite R.;Rhie, Suhn K.;Li, Guo;Liu, Yongmei;Liu, Youfang;Lu, Yingchang;Nalls, Michael A.;Sun, Yan V.;Wojczynski, Mary K.;Yanek, Lisa R.;Aldrich, Melinda C.;Ademola, Adeyinka;Amos, Christopher I.;Bandera, Elisa V.;Bock, Cathryn H.;Britton, Angela;Broeckel, Ulrich;Cai, Quiyin;Caporaso, Neil E.;Carlson, Chris S.;Carpten, John;Casey, Graham;Chen, Wei-Min;Chen, Fang;Chen, Yii-Der I.;Chiang, Charleston W. K.;Coetzee, Gerhard A.;Demerath, Ellen;Deming-Halverson, Sandra L.;Driver, Ryan W.;Dubbert, Patricia;Feitosa, Mary F.;Feng, Ye;Freedman, Barry I.;Gillanders, Elizabeth M.;Gottesman, Omri;Guo, Xiuqing;Haritunians, Talin;Harris, Tamara;Harris, Curtis C.;Hennis, Anselm J. M.;Hernandez, Dena G.;McNeill, Lorna H.;Howard, Timothy D.;Howard, Barbara V.;Howard, Virginia J.;Johnson, Karen C.;Kang, Sun J.;Keating, Brendan J.;Kolb, Suzanne;Kuller, Lewis H.;Kutlar, Abdullah;Langefeld, Carl D.;Lettre, Guillaume;Lohman, Kurt;Lotay, Vaneet;Lyon, Helen;Manson, Joann E.;Maixner, William;Meng, Yan A.;Monroe, Kristine R.;Morhason-Bello, Imran;Murphy, Adam B.;Mychaleckyj, Josyf C.;Nadukuru, Rajiv;Nathanson, Katherine L.;Nayak, Uma;N'Diaye, Amidou;Nemesure, Barbara;Wu, Suh-Yuh;Leske, M. Cristina;Neslund-Dudas, Christine;Neuhouser, Marian;Nyante, Sarah;Ochs-Balcom, Heather;Ogunniyi, Adesola;Ogundiran, Temidayo O.;Ojengbede, Oladosu;Olopade, Olufunmilayo I.;Palmer, Julie R.;Ruiz-Narvaez, Edward A.;Palmer, Nicholette D.;Press, Michael F.;Rampersaud, Evandine;Rasmussen-Torvik, Laura J.;Rodriguez-Gil, Jorge L.;Salako, Babatunde;Schadt, Eric E.;Schwartz, Ann G.;Shriner, Daniel A.;Siscovick, David;Smith, Shad B.;Wassertheil-Smoller, Sylvia;Speliotes, Elizabeth K.;Spitz, Margaret R.;Sucheston, Lara;Taylor, Herman;Tayo, Bamidele O.;Tucker, Margaret A.;Van Den Berg, David J.;Edwards, Digna R. Velez;Wang, Zhaoming;Wiencke, John K.;Winkler, Thomas W.;Witte, John S.;Wrensch, Margaret;Wu, Xifeng;Yang, James J.;Levin, Albert M.;Young, Taylor R.;Zakai, Neil A.;Cushman, Mary;Zanetti, Krista A.;Zhao, Jing Hua;Zhao, Wei;Zheng, Yonglan;Zhou, Jie;Ziegler, Regina G.;Zmuda, Joseph M.;Fernandes, Jyotika K.;Gilkeson, Gary S.;Kamen, Diane L.;Hunt, Kelly J.;Spruill, Ida J.;Ambrosone, Christine B.;Ambs, Stefan;Arnett, Donna K.;Atwood, Larry;Becker, Diane M.;Berndt, Sonja I.;Bernstein, Leslie;Blot, William J.;Borecki, Ingrid B.;Bottinger, Erwin P.;Bowden, Donald W.;Burke, Gregory;Chanock, Stephen J.;Cooper, Richard S.;Ding, Jingzhong;Duggan, David;Evans, Michele K.;Fox, Caroline;Garvey, W. Timothy;Bradfield, Jonathan P.;Hakonarson, Hakon;Grant, Struan F. A.;Hsing, Ann;Chu, Lisa;Hu, Jennifer J.;Huo, Dezheng;Ingles, Sue A.;John, Esther M.;Jordan, Joanne M.;Kabagambe, Edmond K.;Kardia, Sharon L. R.;Kittles, Rick A.;Goodman, Phyllis J.;Klein, Eric A.;Kolonel, Laurence N.;Le Marchand, Loic;Liu, Simin;McKnight, Barbara;Millikan, Robert C.;Mosley, Thomas H.;Padhukasahasram, Badri;Williams, L. Keoki;Patel, Sanjay R.;Peters, Ulrike;Pettaway, Curtis A.;Peyser, Patricia A.;Psaty, Bruce M.;Redline, Susan;Rotimi, Charles N.;Rybicki, Benjamin A.;Sale, Michele M.;Schreiner, Pamela J.;Signorello, Lisa B.;Singleton, Andrew B.;Stanford, Janet L.;Strom, Sara S.;Thun, Michael J.;Vitolins, Mara;Zheng, Wei;Moore, Jason H.;Williams, Scott M.;Ketkar, Shamika;Zhu, Xiaofeng;Zonderman, Alan B.;Kooperberg, Charles;Papanicolaou, George J.;Henderson, Brian E.;Reiner, Alex P.;Hirschhorn, Joel N.;Loos, Ruth J. F.;North, Kari E.;Haiman, Christopher A.
全基因组关联研究（GWAS）已经确定了36个与体重指数（BMI）相关的基因座，主要在欧洲血统的人群中。我们进行了一项荟萃分析，在39，144名非洲血统的男性和女性中检查了> 320万个SNP与BMI的关联，并在另外32，268名非洲血统的个体中随访了最重要的关联。我们在5 q33（GALNT 10，rs7708584，p=3.4×10−11）和7 p15（MIR 148 A/NFE 2L 3，rs 10261878，p=1.2×10−10）发现了一个新的基因座。我们还在非洲血统样本中发现了与6 q16第三个基因座相关的暗示性证据（KLHL 32，rs 974417，p=6.9×10−8）。在我们的GWAS中，36个先前确定的BMI变体中有32个显示出方向一致的效应估计（二项式p=9.7×10−7），其中5个达到了全基因组显著性。这些研究结果提供了强有力的支持共享BMI基因座在人群中，以及研究祖先不同的人群的效用。
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry, and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one novel locus at 5q33 (GALNT10, rs7708584, p=3.4×10−11) and another at 7p15 when combined with data from the Giant consortium (MIR148A/NFE2L3, rs10261878, p=1.2×10−10). We also found suggestive evidence of an association at a third locus at 6q16 in the African ancestry sample (KLHL32, rs974417, p=6.9×10−8). Thirty-two of the 36 previously established BMI variants displayed directionally consistent effect estimates in our GWAS (binomial p=9.7×10−7), of which five reached genome-wide significance. These findings provide strong support for shared BMI loci across populations as well as for the utility of studying ancestrally diverse populations.
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影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
影响因子：
4.8
作者：
Clerc, Pascal;Constans, Maria Gracia Coll;Dufresne, Marlene
通讯作者：
Dufresne, Marlene
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Ehret, Georg B.;Munroe, Patricia B.;Rice, Kenneth M.;Bochud, Murielle;Johnson, Andrew D.;Chasman, Daniel I.;Smith, Albert V.;Tobin, Martin D.;Verwoert, Germaine C.;Hwang, Shih-Jen;Pihur, Vasyl;Vollenweider, Peter;O'Reilly, Paul F.;Amin, Najaf;Bragg-Gresham, Jennifer L.;Teumer, Alexander;Glazer, Nicole L.;Launer, Lenore;Zhao, Jing Hua;Aulchenko, Yurii;Heath, Simon;Sober, Siim;Parsa, Afshin;Luan, Jian'an;Arora, Pankaj;Dehghan, Abbas;Zhang, Feng;Lucas, Gavin;Hicks, Andrew A.;Jackson, Anne U.;Peden, John F.;Tanaka, Toshiko;Wild, Sarah H.;Rudan, Igor;Igl, Wilmar;Milaneschi, Yuri;Parker, Alex N.;Fava, Cristiano;Chambers, John C.;Fox, Ervin R.;Kumari, Meena;Go, Min Jin;van der Harst, Pim;Kao, Wen Hong Linda;Sjogren, Marketa;Vinay, D. G.;Alexander, Myriam;Tabara, Yasuharu;Shaw-Hawkins, Sue;Whincup, Peter H.;Liu, Yongmei;Shi, Gang;Kuusisto, Johanna;Tayo, Bamidele;Seielstad, Mark;Sim, Xueling;Khanh-Dung Hoang Nguyen;Lehtimaki, Terho;Matullo, Giuseppe;Wu, Ying;Gaunt, Tom R.;Onland-Moret, N. Charlotte;Cooper, Matthew N.;Platou, Carl G. P.;Org, Elin;Hardy, Rebecca;Dahgam, Santosh;Palmen, Jutta;Vitart, Veronique;Braund, Peter S.;Kuznetsova, Tatiana;Uiterwaal, Cuno S. P. M.;Adeyemo, Adebowale;Palmas, Walter;Campbell, Harry;Ludwig, Barbara;Tomaszewski, Maciej;Tzoulaki, Ioanna;Palmer, Nicholette D.;Aspelund, Thor;Garcia, Melissa;Chang, Yen-Pei C.;O'Connell, Jeffrey R.;Steinle, Nanette I.;Grobbee, Diederick E.;Arking, Dan E.;Kardia, Sharon L.;Morrison, Alanna C.;Hernandez, Dena;Najjar, Samer;McArdle, Wendy L.;Hadley, David;Brown, Morris J.;Connell, John M.;Hingorani, Aroon D.;Day, Ian N. M.;Lawlor, Debbie A.;Beilby, John P.;Lawrence, Robert W.;Clarke, Robert;Hopewell, Jemma C.;Ongen, Halit;Dreisbach, Albert W.;Li, Yali;Young, J. Hunter;Bis, Joshua C.;Kahonen, Mika;Viikari, Jorma;Adair, Linda S.;Lee, Nanette R.;Chen, Ming-Huei;Olden, Matthias;Pattaro, Cristian;Bolton, Judith A. Hoffman;Koettgen, Anna;Bergmann, Sven;Mooser, Vincent;Chaturvedi, Nish;Frayling, Timothy M.;Islam, Muhammad;Jafar, Tazeen H.;Erdmann, Jeanette;Kulkarni, Smita R.;Bornstein, Stefan R.;Graessler, Juergen;Groop, Leif;Voight, Benjamin F.;Kettunen, Johannes;Howard, Philip;Taylor, Andrew;Guarrera, Simonetta;Ricceri, Fulvio;Emilsson, Valur;Plump, Andrew;Barroso, Ine S.;Khaw, Kay-Tee;Weder, Alan B.;Hunt, Steven C.;Sun, Yan V.;Bergman, Richard N.;Collins, Francis S.;Bonnycastle, Lori L.;Scott, Laura J.;Stringham, Heather M.;Peltonen, Leena;Perola, Markus;Vartiainen, Erkki;Brand, Stefan-Martin;Staessen, Jan A.;Wang, Thomas J.;Burton, Paul R.;Artigas, Maria Soler;Dong, Yanbin;Snieder, Harold;Wang, Xiaoling;Zhu, Haidong;Lohman, Kurt K.;Rudock, Megan E.;Heckbert, Susan R.;Smith, Nicholas L.;Wiggins, Kerri L.;Doumatey, Ayo;Shriner, Daniel;Veldre, Gudrun;Viigimaa, Margus;Kinra, Sanjay;Prabhakaran, Dorairaj;Tripathy, Vikal;Langefeld, Carl D.;Rosengren, Annika;Thelle, Dag S.;Corsi, Anna Maria;Singleton, Andrew;Forrester, Terrence;Hilton, Gina;McKenzie, Colin A.;Salako, Tunde;Iwai, Naoharu;Kita, Yoshikuni;Ogihara, Toshio;Ohkubo, Takayoshi;Okamura, Tomonori;Ueshima, Hirotsugu;Umemura, Satoshi;Eyheramendy, Susana;Meitinger, Thomas;Wichmann, H. -Erich;Cho, Yoon Shin;Kim, Hyung-Lae;Lee, Jong-Young;Scott, James;Sehmi, Joban S.;Zhang, Weihua;Hedblad, Bo;Nilsson, Peter;Smith, George Davey;Wong, Andrew;Narisu, Narisu;Stancakova, Alena;Raffel, Leslie J.;Yao, Jie;Kathiresan, Sekar;O'Donnell, Christopher J.;Schwartz, Stephen M.;Ikram, M. Arfan;Longstreth, W. T., Jr.;Mosley, Thomas H.;Seshadri, Sudha;Shrine, Nick R. G.;Wain, Louise V.;Morken, Mario A.;Swift, Amy J.;Laitinen, Jaana;Prokopenko, Inga;Zitting, Paavo;Cooper, Jackie A.;Humphries, Steve E.;Danesh, John;Rasheed, Asif;Goel, Anuj;Hamsten, Anders;Watkins, Hugh;Bakker, Stephan J. L.;van Gilst, Wiek H.;Janipalli, Charles S.;Mani, K. Radha;Yajnik, Chittaranjan S.;Hofman, Albert;Mattace-Raso, Francesco U. S.;Oostra, Ben A.;Demirkan, Ayse;Isaacs, Aaron;Rivadeneira, Fernando;Lakatta, Edward G.;Orru, Marco;Scuteri, Angelo;Ala-Korpela, Mika;Kangas, Antti J.;Lyytikainen, Leo-Pekka;Soininen, Pasi;Tukiainen, Taru;Wurtz, Peter;Ong, Rick Twee-Hee;Doerr, Marcus;Kroemer, Heyo K.;Voelker, Uwe;Voelzke, Henry;Galan, Pilar;Hercberg, Serge;Lathrop, Mark;Zelenika, Diana;Deloukas, Panos;Mangino, Massimo;Spector, Tim D.;Zhai, Guangju;Meschia, James F.;Nalls, Michael A.;Sharma, Pankaj;Terzic, Janos;Kumar, M. V. Kranthi;Denniff, Matthew;Zukowska-Szczechowska, Ewa;Wagenknecht, Lynne E.;Fowkes, F. Gerald R.;Charchar, Fadi J.;Schwarz, Peter E. H.;Hayward, Caroline;Guo, Xiuqing;Rotimi, Charles;Bots, Michiel L.;Brand, Eva;Samani, Nilesh J.;Polasek, Ozren;Talmud, Philippa J.;Nyberg, Fredrik;Kuh, Diana;Laan, Maris;Hveem, Kristian;Palmer, Lyle J.;van der Schouw, Yvonne T.;Casas, Juan P.;Mohlke, Karen L.;Vineis, Paolo;Raitakari, Olli;Ganesh, Santhi K.;Wong, Tien Y.;Tai, E. Shyong;Cooper, Richard S.;Laakso, Markku;Rao, Dabeeru C.;Harris, Tamara B.;Morris, Richard W.;Dominiczak, Anna F.;Kivimaki, Mika;Marmot, Michael G.;Miki, Tetsuro;Saleheen, Danish;Chandak, Giriraj R.;Coresh, Josef;Navis, Gerjan;Salomaa, Veikko;Han, Bok-Ghee;Zhu, Xiaofeng;Kooner, Jaspal S.;Melander, Olle;Ridker, Paul M.;Bandinelli, Stefania;Gyllensten, Ulf B.;Wright, Alan F.;Wilson, James F.;Ferrucci, Luigi;Farrall, Martin;Tuomilehto, Jaakko;Pramstaller, Peter P.;Elosua, Roberto;Soranzo, Nicole;Sijbrands, Eric J. 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通讯作者：
Johnson, Toby
影响因子：
30.8
作者：
Chambers, John C.;Elliott, Paul;Kooner, Jaspal S.
通讯作者：
Kooner, Jaspal S.