Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis.
Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis.
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DOI：
10.3390/nu9090940
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发表时间：
2017-08-26
期刊：
影响因子：
5.9
通讯作者：
Latella G
中科院分区：
文献类型：
--
作者：
Altobelli E;Del Negro V;Angeletti PM;Latella G
肠易激综合征（IBS）影响7-15%的普通人群。最近设计的饮食方法包括限制具有高度可发酵的寡糖、二糖和单糖以及多元醇（FODMAPs）的食物，这些食物可引发和/或加剧IBS症状。本研究的目的是使用荟萃分析来提供随机对照试验（RCT）和队列研究的最新信息，并分别检查它们与饮食类型的关系。使用系统综述和荟萃分析首选报告项（PRISMA）流程图选择论文。科恩的d和优势比被用来衡量随机对照试验的效果大小。使用随机效应模型来解释研究之间的不同变异来源。使用Q统计量、I2、Tau和Tau 2评估异质性。用漏斗图分析发表偏倚，用Egger检验评估漏斗图对称性。结果表明，在随机对照试验中，与接受传统饮食的患者相比，接受低FODMAP饮食的患者疼痛和腹胀减少具有统计学意义;至于粪便稠度，治疗之间没有显著差异。与接受高FODMAP饮食的患者相比，接受低FODMAP饮食的患者腹痛和腹胀明显减少。在队列研究中，与基线饮食相比，治疗后疼痛和腹胀显著减少。我们的结论是，有证据表明，低FODMAP饮食可能对IBS症状，特别是腹痛和腹胀产生有利影响。然而，低FODMAP饮食是否上级传统的IBS饮食，特别是从长期来看，仍有待证明。
Irritable bowel syndrome (IBS) affects 7–15% of the general population. A recently devised dietary approach consists of restricting foods with highly fermentable oligo-, di-, and monosaccharides, and polyols (FODMAPs), which can trigger and/or exacerbate IBS symptoms. The aim of this study is to use meta-analysis to provide an update on the randomised control trials (RCTs) and cohort studies, and examine them separately in relation to diet type. Papers were selected using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. Cohen’s d and odds ratios were used as a measure of effect size for RCTs. A random effects model was used to account for different sources of variation among studies. Heterogeneity was assessed using Q statistics, I2, Tau, and Tau2. Publication bias was analysed and represented by a funnel plot, and funnel plot symmetry was assessed with Egger’s test. The results showed that in the RCTs, the patients receiving a low-FODMAP diet experienced a statistically significant pain and bloating reduction compared with those receiving a traditional diet; as regards to stool consistency, there was no significant difference between treatments. A significant reduction in abdominal pain and bloating were described by patients receiving a low-FODMAP diet compared with those receiving a high-FODMAP diet. In cohort studies, pain and bloating were significantly reduced after treatment compared with the baseline diet. We conclude that there is evidence that a low-FODMAP diet could have a favourable impact on IBS symptoms, especially abdominal pain and bloating. However, it remains to be demonstrated whether a low-FODMAP diet is superior to conventional IBS diets, especially in the long term.
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DOI：
10.1097/01.naj.0000431911.65473.35
发表时间：
2013-07
期刊：
The American journal of nursing
影响因子：
--
作者：
Anastasi JK;Capili B;Chang M
通讯作者：
Chang M
影响因子：
4.3
作者：
El-Salhy, Magdy;Gundersen, Doris;Hausken, Trygve
通讯作者：
Hausken, Trygve
影响因子：
24.5
作者：
Camilleri, Michael;Boeckxstaens, Guy
通讯作者：
Boeckxstaens, Guy
影响因子：
2.6
作者：
de Roest, R. H.;Dobbs, B. R.;Gearry, R. B.
通讯作者：
Gearry, R. B.
影响因子：
5.9
作者：
Catassi G;Lionetti E;Gatti S;Catassi C
通讯作者：
Catassi C