Naloxone-precipitated morphine withdrawal elicits increases in c-fos mRNA expression in restricted regions of the infant rat brain.
Naloxone-precipitated morphine withdrawal elicits increases in c-fos mRNA expression in restricted regions of the infant rat brain.
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纳洛酮促进吗啡戒断会引起幼鼠大脑受限区域中 c-fos mRNA 表达的增加。
DOI：
10.1254/jjp.90.270
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Hiro‐aki Yamamoto
中科院分区：
文献类型：
--
作者：
T. Maeda;S. Kishioka;N. Inoue;N. Shimizu;Y. Fukazawa;M. Ozaki;Hiro‐aki Yamamoto
本文首次报道了幼年大鼠吗啡戒断的遗传指标。我们研究了纳洛酮（2 mg/kg）对吗啡重复处理（20 mg/kg，每日一次，连续5d）后幼年和成年大鼠脑内c-fos mRNA水平的影响。单次给药纳洛酮（纳洛酮激发）后1h，在幼年大鼠嗅球、下丘脑和延髓中观察到c-fos mRNA的增加，在成年大鼠嗅球和下丘脑中观察到c-fos mRNA的增加，但在延髓中未观察到c-fos mRNA的增加。在纳洛酮刺激后6 h，c-fos mRNA水平恢复至对照水平。在婴儿和成年大鼠中，c-fos mRNA水平的增加伴随着体重减轻。当MK-801，一种非竞争性的N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，与吗啡沿着给药时，它抑制了纳洛酮诱导的c-fos mRNA水平的增加，在反复给药吗啡后的幼年大鼠。这些结果表明，身体依赖性的发展，在婴儿大鼠重复吗啡给药后，c-fos mRNA水平的增加是一个有用的指标纳洛酮催促吗啡戒断在婴儿以及在成年大鼠。
This paper is the first report of a genetic index for morphine withdrawal in infant rats. We examined the effects of naloxone (2 mg/kg) on c-fos mRNA levels in brains of infant and adult rats following repeated treatment with morphine (20 mg/kg, once daily for 5 days). One hour after a single administration of naloxone (naloxone challenge), an increase in c-fos mRNA was observed in the olfactory bulb, hypothalamus and medulla oblongata of infant rats, and in the olfactory bulb and hypothalamus, but not in the medulla oblongata of adult rats. The c-fos mRNA levels returned to control levels 6 h after the naloxone challenge. The increase in c-fos mRNA levels was followed by body weight loss in both infant and adult rats. When MK-801, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, was co-administered along with morphine, it inhibited the naloxone-induced increases in c-fos mRNA levels in infant rats following repeated morphine administration. These results suggest that physical dependence develops in infant rats following repeated morphine administration and that the increment of c-fos mRNA levels is a useful indicator for naloxone-precipitated morphine withdrawal in infant as well as in adult rats.
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影响因子：
56.9
作者：
TRUJILLO, KA;AKIL, H
通讯作者：
AKIL, H
N-甲基-D-天冬氨酸受体拮抗剂之间的相互作用与吗啡对大鼠的辨别刺激作用。
DOI：
10.1016/s0091-3057(98)00006-9
发表时间：
1998
期刊：
Pharmacology, biochemistry, and behavior
影响因子：
--
作者：
Bespalov,AY;Beardsley,PM;Balster,RL
通讯作者：
Balster,RL
突然的吗啡戒断会刺激大鼠大脑中的多个激活蛋白 1 信号通路。
DOI：
--
发表时间：
1995
期刊：
Molecular pharmacology.
影响因子：
--
作者：
Couceyro,P;Douglass,J
通讯作者：
Douglass,J
大鼠吗啡戒断的个体发育。
影响因子：
1.9
作者：
Jones,KL;Barr,GA
通讯作者：
Barr,GA