Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence.
Selenoprotein and antioxidant genes and the risk of high-grade prostate cancer and prostate cancer recurrence.
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DOI：
10.1002/pros.22892
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发表时间：
2015-01
期刊：
影响因子：
2.8
通讯作者：
Chan, June M.
中科院分区：
文献类型：
--
作者：
Gerstenberger, John P.;Bauer, Scott R.;Van Blarigan, Erin L.;Sosa, Eduardo;Song, Xiaoling;Witte, John S.;Carroll, Peter R.;Chan, June M.
观察性研究表明，硒与前列腺癌风险之间存在负相关。然而，补硒的随机对照试验报告了相互矛盾的结果。因此，我们在最初诊断为非转移性疾病的男性中检测了血浆硒和硒相关基因与高级别前列腺癌和前列腺癌复发风险的关系。我们检测了568例前列腺癌根治术患者的血浆硒水平，并检测了其TXNRD1、TXNRD2、GPX1、GPX3、Gpx4、SEP15、SEPP1、SELENBP1、OGG1和CAT基因的73个单核苷酸多态性。我们用Logistic回归分析了血浆硒、基因分型与高级别前列腺癌风险(格里森分级≥8或7，初评≥4；n=111)和前列腺癌复发风险(61个事件；3.8y中位数随访)之间的关系，采用COX比例风险回归。血浆硒与高级别前列腺癌或前列腺癌复发的风险无关。TXNRD2基因rs11913319和OGG1基因rs125701不太常见的等位基因与高级别前列腺癌的风险增加相关。我们观察了前列腺癌复发风险与TXNRD1、TXNRD2、GPX3和SEP15的多个SNP之间的关系。在对多重比较进行调整后，这些相关性在统计上不再显著。在患有非转移性前列腺癌的男性中，有提示证据表明，硒蛋白和相关抗氧化酶的基因变异可能与确诊时的高级别疾病风险和前列腺癌复发有关。
Observational studies suggest an inverse association between selenium and risk of prostate cancer. However, randomized controlled trials of selenium supplementation have reported conflicting results. Thus, we examined plasma selenium and selenium-related genes in relation to risk of high-grade prostate cancer and prostate cancer recurrence among men initially diagnosed with non-metastatic disease. We measured plasma selenium and genotyped 73 single nucleotide polymorphisms in TXNRD1, TXNRD2, GPX1, GPX3, GPX4, SEP15, SEPP1, SELENBP1, OGG1, and CAT among 568 men with non-metastatic prostate cancer who underwent radical prostatectomy. We examined associations between plasma selenium, genotypes, and risk of high-grade prostate cancer (Gleason grade ≥8 or 7 with primary score ≥4; n=111) using logistic regression, and risk of prostate cancer recurrence (61 events; 3.8 y median follow-up) using Cox proportional hazards regression. Plasma selenium was not associated with risk of high-grade prostate cancer or prostate cancer recurrence. Less common alleles of rs11913319 in TXNRD2 and rs125701 in OGG1 were associated with an increased risk of high-grade prostate cancer. We observed associations between the risk of prostate cancer recurrence and multiple SNPs in TXNRD1, TXNRD2, GPX3, and SEP15. These associations were no longer statistically significant after adjustment for multiple comparisons. Among men with non-metastatic prostate cancer, there is suggestive evidence that genetic variation in selenoproteins and related antioxidant enzymes may be associated with risk of high-grade disease at diagnosis and prostate cancer recurrence.
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DOI：
10.1002/pros.22717
发表时间：
2013-12
期刊：
The Prostate
影响因子：
--
作者：
Bauer SR;Richman EL;Sosa E;Weinberg V;Song X;Witte JS;Carroll PR;Chan JM
通讯作者：
Chan JM
影响因子：
5.7
作者：
Ding WX;Ni HM;Gao W;Chen X;Kang JH;Stolz DB;Liu J;Yin XM
通讯作者：
Yin XM
影响因子：
2
作者：
Arsova-Sarafinovska, Zorica;Matevska, Nadica;Dimovski, Aleksandar J.
通讯作者：
Dimovski, Aleksandar J.
影响因子：
10.3
作者：
Geybels, Milan S.;van den Brandt, Piet A.;Verhage, Bas A. J.
通讯作者：
Verhage, Bas A. J.
影响因子：
11.2
作者：
Cooper ML;Adami HO;Grönberg H;Wiklund F;Green FR;Rayman MP
通讯作者：
Rayman MP