Antioxidant and vitamin E transport genes and risk of high-grade prostate cancer and prostate cancer recurrence.
Antioxidant and vitamin E transport genes and risk of high-grade prostate cancer and prostate cancer recurrence.
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DOI：
10.1002/pros.22717
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Chan JM
中科院分区：
文献类型：
--
作者：
Bauer SR;Richman EL;Sosa E;Weinberg V;Song X;Witte JS;Carroll PR;Chan JM
观察性研究表明，维生素 E 与前列腺癌（尤其是侵袭性肿瘤）的风险呈负相关。然而，三项大型随机对照试验报告了相互矛盾的结果。因此，我们检查了最初诊断为临床器官局限性疾病的男性中循环维生素 E 和维生素 E 相关基因与高级别前列腺癌和前列腺癌复发风险的关系。我们测量了 573 名接受根治性前列腺切除术的器官局限性前列腺癌患者的循环 α- 和 γ-生育酚，并对 SOD1、SOD2、SOD3、TTPA 和 SEC14L2 中的 30 个 SNP 进行了基因分型。我们使用 Logistic 回归检查了循环维生素 E、基因型和高级别前列腺癌风险（格里森分级 ≥ 8 或 7 级，初级评分 ≥ 4；n = 117）之间的关联，并使用 Cox 比例风险回归检查了复发风险（56 个事件；中位随访 3.7 年）之间的关联。循环中的γ-生育酚与高级别前列腺癌的风险增加相关（Q4 与 Q1 比值比 [OR] = 1.87；95% 置信区间 [CI]：0.97–3.58；Ptrend = 0.02）。 SOD3 rs699473 中不太常见的等位基因与重度疾病的风险增加相关（T > C：OR = 1.40，95% CI：1.04–1.89）。在相加模型中，SOD1 中的两个独立 SNP 与前列腺癌复发呈负相关（rs17884057 风险比 [HR] = 0.49，95% CI：0.25–0.96；rs9967983 HR = 0.62，95% CI：0.40–0.95）。在患有临床器官局限性前列腺癌的男性中，SOD 的遗传变异可能与诊断时的重度疾病和疾病复发的风险相关。循环中的 γ-生育酚水平也可能与诊断时患重度疾病的风险增加有关。
Observational studies suggest an inverse association between vitamin E and risk of prostate cancer, particularly aggressive tumors. However, three large randomized controlled trials have reported conflicting results. Thus, we examined circulating vitamin E and vitamin E-related genes in relation to risk of high-grade prostate cancer and prostate cancer recurrence among men initially diagnosed with clinically organ-confined disease. We measured circulating α- and γ-tocopherol and genotyped 30 SNPs in SOD1, SOD2, SOD3, TTPA, and SEC14L2 among 573 men with organ-confined prostate cancer who underwent radical prostatectomy. We examined associations between circulating vitamin E, genotypes, and risk of high-grade prostate cancer (Gleason grade ≥ 8 or 7 with primary score ≥ 4; n = 117) using logistic regression, and risk of recurrence (56 events; 3.7 years median follow-up) using Cox proportional hazards regression. Circulating γ-tocopherol was associated with an increased risk of high-grade prostate cancer (Q4 v. Q1 odds ratio [OR] = 1.87; 95% confidence intervals [CI]: 0.97–3.58; Ptrend = 0.02). The less common allele in SOD3 rs699473 was associated with an increased risk of high-grade disease (T > C: OR = 1.40, 95% CI: 1.04–1.89). Two independent SNPs in SOD1 were inversely associated with prostate cancer recurrence in additive models (rs17884057 hazard ratio [HR] = 0.49, 95%CI: 0.25–0.96; rs9967983 HR = 0.62, 95% CI: 0.40–0.95). Among men with clinically organ-confined prostate cancer, genetic variation in SOD may be associated with risk of high-grade disease at diagnosis and disease recurrence. Circulating γ-tocopherol levels may also be associated with an increased risk of high-grade disease at diagnosis.
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影响因子：
10.3
作者：
Kirsh, VA;Hayes, RB;Peters, U
通讯作者：
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