Uric acid as a target of therapy in CKD.
Uric acid as a target of therapy in CKD.
复制标题
DOI：
10.1053/j.ajkd.2012.07.021
复制
发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Targher G
中科院分区：
文献类型：
--
作者：
Jalal DI;Chonchol M;Chen W;Targher G
在美国和世界范围内，慢性肾脏疾病（CKD）的患病率已经上升，并将继续上升。考虑到CKD仍然是一种不可逆转的疾病，进展为慢性肾衰竭的患者生活质量下降，死亡率高，这是令人担忧的。因此，必须确定可改变的风险因素，以制定减缓CKD进展的策略。其中一个因素是高尿酸血症。最近的观察性研究将高尿酸血症与肾脏疾病联系起来。此外，高尿酸血症在CKD患者中普遍存在。来自实验研究的数据揭示了高尿酸血症可能促进CKD发生和进展的几种潜在机制。在这篇论文中，我们对高尿酸血症与CKD相关的实验证据进行了批判性的回顾，我们强调了目前在这一主题上的知识差距，我们回顾了观察性和干预性研究，这些研究已经检查了降低CKD患者尿酸的潜在肾保护作用。虽然尿酸也可能与CKD患者的心血管疾病和死亡率有关，但本综述将仅关注尿酸作为预防肾脏疾病发生和进展的潜在治疗靶点。
The prevalence of chronic kidney disease (CKD) has risen and will continue to rise in the United States and worldwide. This is alarming considering that CKD remains an irreversible condition and patients who progress to chronic kidney failure suffer reduced quality of life and high mortality rates. As such, it is imperative to identify modifiable risk factors to develop strategies to slow CKD progression. One such factor is hyperuricemia. Recent observational studies have associated hyperuricemia with kidney disease. In addition, hyperuricemia is largely prevalent in patients with CKD. Data from experimental studies have revealed several potential mechanisms by which hyperuricemia may contribute to the development and progression of CKD. In this manuscript we offer a critical review of the experimental evidence linking hyperuricemia to CKD, we highlight the gaps in our knowledge on the topic as it stands today, and we review the observational and interventional studies that have examined the potential nephro-protective effect of lowering uric acid in CKD patients . While uric acid may also be linked to cardiovascular disease and mortality in patients with CKD, this review will focus only on uric acid as a potential therapeutic target to prevent kidney disease onset and progression.
登录
查看更多内容
DOI：
10.1152/ajprenal.00104.2006
发表时间：
2007-01-01
影响因子：
4.2
作者：
Han, Ho Jae;Lim, Min Jin;Taub, Mary
通讯作者：
Taub, Mary
影响因子：
64.8
作者：
Enomoto, A;Kimura, H;Endou, H
通讯作者：
Endou, H
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
5.9
作者：
HANDE, KR;NOONE, RM;STONE, WJ
通讯作者：
STONE, WJ
影响因子：
0.9
作者：
Akgul, A.;Bilgic, A.;Haberal, M.
通讯作者：
Haberal, M.