Cell atrophy and loss in depression: reversal by antidepressant treatment.
Cell atrophy and loss in depression: reversal by antidepressant treatment.
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DOI：
10.1016/j.ceb.2011.09.002
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发表时间：
2011-12
影响因子：
7.5
通讯作者：
Duman, Ronald S.
中科院分区：
文献类型：
--
作者：
Banasr, Mounira;Dwyer, Jason M.;Duman, Ronald S.
抑郁症与控制情绪和情绪的大脑边缘区域的结构改变有关。对动物模型和抑郁症患者死后组织的慢性应激研究表明，这些结构变化是神经元和神经胶质细胞萎缩和丧失的结果。这些发现表明，抑郁症和压力相关的情绪障碍可以被认为是轻度神经退行性疾病。重要的是，有证据表明，这些结构改变可以通过消除压力和抗抑郁治疗来阻断甚至逆转。当前研究的一个主要焦点是表征压力、抑郁和抗抑郁治疗的分子信号通路和因素。在这一研究领域的最新进展进行了讨论，并强调了潜在的抗抑郁药开发的新目标。
Depression is associated with structural alterations in limbic brain regions that control emotion and mood. Studies of chronic stress in animal models and postmortem tissue from depressed subjects demonstrate that these structural alterations result from atrophy and loss of neurons and glial cells. These findings indicate that depression and stress-related mood disorders can be considered mild neurodegenerative disorders. Importantly, there is evidence that these structural alterations can be blocked or even reversed by elimination of stress and by antidepressant treatments. A major focus of current investigations is to characterize the molecular signaling pathways and factors that underlie these effects of stress, depression, and antidepressant treatment. Recent advances in this research area are discussed and potential novel targets for antidepressant development are highlighted.
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影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
影响因子：
2.5
作者：
Bachis A;Cruz MI;Nosheny RL;Mocchetti I
通讯作者：
Mocchetti I
DOI：
10.1017/s1461145704004535
发表时间：
2004-12-01
影响因子：
4.8
作者：
Gould, TD;Einat, H;Manji, HK
通讯作者：
Manji, HK
影响因子：
10.6
作者：
aan het Rot, Marije;Collins, Katherine A.;Mathew, Sanjay J.
通讯作者：
Mathew, Sanjay J.
影响因子：
11
作者：
Dwivedi, Y;Rizavi, HS;Pandey, GN
通讯作者：
Pandey, GN